Table 1 Studies demonstrating the efficacy of MSC-based therapies for the treatment of ischemic stroke in rodent models
From: Mesenchymal stem cell-based therapy for ischemic stroke
Author | Type of Cells | Stroke model | Delivery | Effect | Histology | Outcomes |
|---|---|---|---|---|---|---|
Brenneman, M | BM-MSC (Rat) | CCAO/MCAO | 24 h | Y | TCC, TUNEL, DAPI, Fluorescein | Decreased infarct |
Chen J | BM-MSC (Rat) | MCAO | 24 h | Y | H&E, Y chr, TUNEL | Increased rotarod, adhesive |
Chen, JR | BM-MSCs (Rat) | MCAO | Immediate | Y | Nissel, GFAP, GalC, MAP2, Tuj1, BrdU | Decreased infarct |
Doeppner TR | BM MSC & Exosomes (Human) | MCAO | Days 1,3,5 | Y | cresyl violet, Neun, BrdU | Increase rotarod, tightrope |
Goldmacher, GV | BM-MSCs (rat) | MCAO | Immediate | Y | TTC, HNA, GFAP, CD11 | Decreased nMSS |
Fernandez, M | Adipose-MSC (Human, Rat) | Permanent MCAO | 30 mins | Y | H&E, TUNEL, GFAP. VEGF, SYP, DAPI | Decreased cell death |
Honma, T | MCS-Telomerase (Human) | MCAO | 12 h | Y | H&E, TTC. Beta-gal, NeuN, GFAP | Decreased infarct, inflammation |
Koh, SH | UC-MSC (Human) | MCAO | 2 weeks | Y | Neun, SNE, GFAP, nestin | Decreased nMSS |
Li Y | BM-MSC (Human) | MCAO | 1 day | Y | H&E, NeuN, MAP-2, GFAP, vWF, TUNEL | Decreased mNSS |
Lim, JY | UC-MSC (Human) | MCAO | 72 h | Y | TTC, NeuN, GFAP, DAPI, TUNEL | Decreased infarct |
Liu, N | BM-MSC-SVV (Rat) | MCAO | 26 h | Y | TCC, NeuN, GFP | Decreased infarct |
Nomura, T | BM-MSC-BDNF (Human) | MCAO | 6 h | Y | TCC, Beta-gal, NeuN, GFAP | Decreased infarct |
Quittet MS | BM-MSC-PAM-VEGF (Rat) | MCAO | 24 h | N | BrdU, NeuN, GFAP, CASP2, DCX, Ki67 | No Difference |
Wei, L | BM-MSC (Rat) | MCAO | 24 h | Y | BrdU, NeuN, MAP2, GFAP, Tuj1, lba-1 | Increased rotarod |
Yamauchi T | BM-MSC (Human) | Permanent MCAO | 7 days | Y | Tuj-1, NeuN, GFAP | Increased rotarod, radial maze |
Yang C | BM-MSC-HIF1a (Rat) | MCAO | 6 h | Y | TTC, CD105 | Decreased infarct, nMSS |
Toyoshima, A | BM-MSC (Rat) | MCAO | 24 h | Y | DAPI, Q-Tracker, TCC | Decreased infarct, nMSS |
Xin. H | BM-MSC (Rat) | MCAO | 24 h | Y | BDA-DAB, NF-200, SYP | Decreased adhesive, foot-fault |
Xin. H | BM-MSC (Mouse) | MCAO | 24 h | Y | Nissl, Luxol, SYP, Apo-TAG | Increased neurites, plasticity |
Lowrance, SA | BM-MSC (Rat) | MCAO | 7 days | Y | Hoescht, GFAP | Decreased SORT |