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Table 2 Univariable and multivariable logistic regression analyses based on the imputed datasets for the final model

From: Predictors and dynamic online nomogram for postoperative delayed hyponatremia after endoscopic transsphenoidal surgery for pituitary adenomas: a single-center, retrospective, observational cohort study with external validation

Characteristics

Univariate analysis

Multivariate analysis

Coefficient

OR

P

Coefficient

OR

P

Age (year)

0.02

1.02

0.147

   

Gender

 Female

Reference

     

 Male

 − 0.14

0.87

0.646

   

Clinical subtype

 Nonfunctioning

Reference

     

 PRL secreting

0.83

2.28

0.160

   

 GH secreting

 − 0.05

0.95

0.898

   

 ACTH secreting

 − 0.30

0.74

0.716

   

 PRL-GH secreting

 − 0.22

0.80

0.852

   

Preoperative hyponatremia

 No

Reference

     

 Yes

0.21

1.23

0.749

   

Hyponatremia on POD 1–2

 No

Reference

     

 Yes

0.75

2.11

0.088*

0.97

2.64

0.033**

Polyuria

 No

Reference

     

 Yes

0.25

1.28

0.489

   

Visual impairment

 No

Reference

     

 Yes

0.68

1.97

0.028**

   

Hardy grade for suprasellar extension

 0

Reference

     

 A

 − 0.71

0.49

0.160

   

 B

 − 0.08

0.92

0.842

   

 C

0.57

1.76

0.175

   

 D

0.98

2.67

0.348

   

 E

1.39

4.01

0.150

   

Hardy grade for sellar invasion

 Noninvasive

Reference

     

 Invasive

0.41

1.51

0.204

   

Knosp grade

 Noninvasive

Reference

     

 Invasive

0.42

1.52

0.200

   

Tumor shape 1

 In sella

Reference

     

 Ellipsoid

 − 0.49

0.62

0.328

   

 Hourglass sign

0.25

1.29

0.517

   

Tumor shape 2

 Not lobulated

Reference

     

 Lobulated

0.45

1.58

0.355

   

Log10 (FSH) (IU/L)

0.84

2.32

0.020**

   

FT3 (pmol/L)

 − 0.54

0.58

0.012**

   

WBC count (109/L)

 − 0.30

0.74

0.012**

   

Monocyte percentage (%)

0.20

1.22

0.032**

0.20

1.22

0.047**

PT (s)

0.57

1.76

0.006**

0.58

1.78

0.008**

INR

5.42

226.26

0.017**

   

Total bilirubin (μmol/L)

 − 0.05

0.95

0.082*

   

Chlorine (mmol/L)

0.06

1.06

0.277

   
  1. PRL secreting Prolactin secreting, GH secreting Growth hormone secreting, ACTH secreting Adrenocorticotropic hormone secreting, POD Postoperative day, FSH Follicle-stimulating hormone, FT3 Free triiodothyronine, WBC White blood cell, PT Prothrombin time, INR International normalized ratio, OR Odds ratio
  2. *Marginal statistical significance (P < 0.1)
  3. **Statistical significance (P < 0.05)