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Fig. 5 | Chinese Neurosurgical Journal

Fig. 5

From: Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood–brain barrier dysfunction

Fig. 5

GLC pretreatment prevented BBB destruction following W-ICH. Representative confocal images of BBB tight junction protein ZO-1 (A) and Occludin (C) in the perihematomal area at 24 h after W-ICH. The arrow indicates the breakdown of the continuous endothelial cell layer. Scale bar = 20 µm. Representative bands and relative density analyses of the ZO-1 (B) and Occludin (D) expression in the perihematomal area at 24 h after W-ICH (n = 6). Data are shown as mean ± SD. *P < 0.05; **P < 0.01

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