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Table 4 Ongoing studies concerning the application of ELD

From: Some cool considerations of external lumbar drainage during its widespread application in neurosurgical practice: a long way to go


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Charite University, Berlin, Germany

December 2010

Single blind, Randomized

EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH

To investigate whether drainage of cerebral spinal fluid via a lumbar route will improve outcome after intracranial SAH

University of Erlangen-Nürnberg Medical School

June 2010

Open label, Randomized

A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage

To determine if usage of early lumbar drainage leads to less shunt surgery and less catheter associated complications in patients with communicating hydrocephalus after intracerebral hemorrhage with severe ventricular involvement

Odense University Hospital

August 2013

Open label, Randomized

Use of Lumbar Drain to Remove Clots in Patients Admitted to the Neuro-ICU After Subarachnoid Hemorrhage

To test if CSF obtained from ELD has a higher concentration of blood than CSF from external ventricular drain in patients suffering from SAH

University of British Columbia

March 2008

Single blind, Non-Randomized

Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in the Treatment of Acute Spinal Cord Injury (SCI)

To evaluate CSF drainage as a potential neuroprotective strategy after acute spinal cord injury

St. Joseph’s Hospital and Medical Center, Phoenix

October 2, 2015

Open label, Randomized

Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury

To evaluate the safety and efficacy of CSFD and to provide a preliminary clinical efficacy evaluation of the combination of CSFD and elevation of mean arterial pressure in patients with acute spinal cord injury