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Table 4 Ongoing studies concerning the application of ELD

From: Some cool considerations of external lumbar drainage during its widespread application in neurosurgical practice: a long way to go

Sponsor Start Date Design Brief title Aim
Charite University, Berlin, Germany December 2010 Single blind, Randomized EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH To investigate whether drainage of cerebral spinal fluid via a lumbar route will improve outcome after intracranial SAH
University of Erlangen-Nürnberg Medical School June 2010 Open label, Randomized A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage To determine if usage of early lumbar drainage leads to less shunt surgery and less catheter associated complications in patients with communicating hydrocephalus after intracerebral hemorrhage with severe ventricular involvement
Odense University Hospital August 2013 Open label, Randomized Use of Lumbar Drain to Remove Clots in Patients Admitted to the Neuro-ICU After Subarachnoid Hemorrhage To test if CSF obtained from ELD has a higher concentration of blood than CSF from external ventricular drain in patients suffering from SAH
University of British Columbia March 2008 Single blind, Non-Randomized Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in the Treatment of Acute Spinal Cord Injury (SCI) To evaluate CSF drainage as a potential neuroprotective strategy after acute spinal cord injury
St. Joseph’s Hospital and Medical Center, Phoenix October 2, 2015 Open label, Randomized Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury To evaluate the safety and efficacy of CSFD and to provide a preliminary clinical efficacy evaluation of the combination of CSFD and elevation of mean arterial pressure in patients with acute spinal cord injury