Fig. 1

Histological and behavioral indices of MCAO at 72 h post-stroke. Coronal brain sections of rat subjected to MCAO displayed significant cortical and subcortical infarction (white) when processed in TTC staining (a). These cerebral infarcts were associated with neurological deficits (b). Quantification of cerebral infarcts showed about 45% of the ipsilateral hemisphere infarcted compared to the contralateral intact hemisphere (c). Quantification of neurological deficits showed that rats subjected to MCAO surgery exhibited impairment in the extension of their contralateral forelimbs (d)