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Table 2 Characteristics of included studies

From: Decompressive craniectomy for malignant middle cerebral artery infarctions: a meta-analysis

  Study design No. of patients
(DC/total)
Age
(Mean ± SD)
Sex
(Male/Female)
Time to treatment Duration of follow-up NIHSS
DECIMAL 2007 [13] RCT 20/38 43.5 ± 9.7 9/11 12–36 h 6, 12 22.5 (16–35)
43.3 ± 7.1 9/9 23.4 (17–38)
DESTINY 2007 [14] RCT 17/32 43.2 ± 9.7 8/9 12–36 h 6, 12 21 (19–26)
46.1 ± 8.4 7/8 24 (19–31)
DESTINY II 2014 [15] RCT 49/112 70 (62–82) 25/24 <48 h 6, 12 20 (15–40)
70 (61–80) 31/32 21 (15–38)
HAMLET [16] RCT 32/64 50.0 ± 8.3 20/12 <96 h 3, 6, 12 23 (17–34)
47.4 ± 9.8 18/14 24 (20–36)
HAMLET II [17] RCT 32/64 50.0 ± 8.3 20/12 <96 h 3, 6, 12, 36 23 (17–34)
47.4 ± 9.8 18/14 24 (20–36)
HeADDFIRST [18] RCT 14/24 52.3 (45–59) 9/5 <96 h 6 N/A
57.9 (45–66) 6/4
Slezins 2012 [19] RCT 11/24 57.2 (49–81) N/A <48 h 12 21.2 (16–28)
65.0 (49–81) 20.8 (17–24)
Zhao 2012 [20] RCT 24/47 63.5 (29–78) 6/18 <48 h 6, 12 N/A
64.0 (32–80) 7/16
Mohammed 2014 [21] R 90/125 53.8 ± 7.1 (34–35) N/A <24 h 3, 6 N/A
Rai 2014 [22] P 36/60 44.3 ± 12.23 27/16 <148 h 3, 6, 12 19.0 ± 3.3
57.12 ± 19.28 18.4 ± 3.8
Tsai 2012 [23] P 37/79 65.5 ± 15.8 18/19 <48 h 6 N/A
75.9 ± 13.8 22/20
Yang 2015 [24] R 10/24 58.7 ± 19.3 5/5 120 h 3 16.1 ± 1.9
65.9 ± 16.5 10/4 16.5 ± 2.4
Yu 2012 [25] R 58/131 62.1 ± 12.4 35/23 <48 h 6 16.2
72.6 ± 9.4 36/37 16.8
Rahamnian 2014 [26] P 30/60 59.0 ± 13.5 22/29 <48 h 3 N/A
62.1 ± 11.0 16.14
  1. R Retrospective, P Prospective, DECIMAL decompressive craniectomy in malignant middle cerebral artery infarction, DESTINY Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery, HAMLET Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke, HeADDFIRST Hemicraniectomy and durotomy upon deterioration from infarction-related swelling trial