Table 2 Characteristics of included studies

DECIMAL 2007 [13]

RCT

20/38

43.5 ± 9.7

9/11

12–36 h

6, 12

22.5 (16–35)

43.3 ± 7.1

9/9

23.4 (17–38)

DESTINY 2007 [14]

RCT

17/32

43.2 ± 9.7

8/9

12–36 h

6, 12

21 (19–26)

46.1 ± 8.4

7/8

24 (19–31)

DESTINY II 2014 [15]

RCT

49/112

70 (62–82)

25/24

<48 h

6, 12

20 (15–40)

70 (61–80)

31/32

21 (15–38)

HAMLET [16]

RCT

32/64

50.0 ± 8.3

20/12

<96 h

3, 6, 12

23 (17–34)

47.4 ± 9.8

18/14

24 (20–36)

HAMLET II [17]

RCT

32/64

50.0 ± 8.3

20/12

<96 h

3, 6, 12, 36

23 (17–34)

47.4 ± 9.8

18/14

24 (20–36)

HeADDFIRST [18]

RCT

14/24

52.3 (45–59)

9/5

<96 h

6

N/A

57.9 (45–66)

6/4

Slezins 2012 [19]

RCT

11/24

57.2 (49–81)

N/A

<48 h

12

21.2 (16–28)

65.0 (49–81)

20.8 (17–24)

Zhao 2012 [20]

RCT

24/47

63.5 (29–78)

6/18

<48 h

6, 12

N/A

64.0 (32–80)

7/16

Mohammed 2014 [21]

R

90/125

53.8 ± 7.1 (34–35)

N/A

<24 h

3, 6

N/A

Rai 2014 [22]

P

36/60

44.3 ± 12.23

27/16

<148 h

3, 6, 12

19.0 ± 3.3

57.12 ± 19.28

18.4 ± 3.8

Tsai 2012 [23]

P

37/79

65.5 ± 15.8

18/19

<48 h

6

N/A

75.9 ± 13.8

22/20

Yang 2015 [24]

R

10/24

58.7 ± 19.3

5/5

120 h

3

16.1 ± 1.9

65.9 ± 16.5

10/4

16.5 ± 2.4

Yu 2012 [25]

R

58/131

62.1 ± 12.4

35/23

<48 h

6

16.2

72.6 ± 9.4

36/37

16.8

Rahamnian 2014 [26]

P

30/60

59.0 ± 13.5

22/29

<48 h

3

N/A

62.1 ± 11.0

16.14