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Fig. 4 | Chinese Neurosurgical Journal

Fig. 4

From: Development of fusiform aneurysms induced by topical application of elastase in a rabbit model

Fig. 4

a-d Histological Analysis of Aneurysm (Transverse sections) H&E staining shows a thin aneurysm wall and enlarged inner diameter of aneurysm (b × 40, d × 200) compared to the normal vessel (a × 40, c × 200). e-h Elastic Van Gieson staining of Vertical sections (e × 40), reveals severe destruction of elastic lamina in the aneurysms Elastic fibers (arrow): dark blue to black; nuclei: black; collagen: red; other structures: yellow. Immunohistochemical staining (f × 100) shows a lack of intimal endothelial (CD31 (yellow) positive) cells (arrow) in the intimal endothelial (CD31 (yellow) positive) cells (arrow). Immunofluorescence staining demonstrates that the thickening of the smooth muscle (α-SMA (red) positive) cell layer was decreased and the structure of smooth muscle was disordered (g × 40), compared to the normal layer of smooth muscle (h × 40)

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