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Table 1 Patient characteristics

From: Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center

Variables No. % No. of BM Incidence of BM P value
Median age (years) 63(32-89)   36 19.1  
Age 0.077
 < 60 79 42.0 20 25.3
 ≥ 60 109 58.0 16 14.7
Gender 0.002
 Male 163 86.7 27 16.6
 Female 25 13.3 9 36.0
Stage <0.001
 I 15 7.9 1 6.7
 II 24 12.8 1 4.2
 III 96 51.1 12 12.5
 IV 53 28.2 22 41.5
T status 0.36
 T1-2 121 64.4 25 20.6
 T3-4 67 35.6 11 16.4
N status 0.85
 N0-1 65 34.5 13 20.0
 N2-3 123 65.5 23 18.6
EGFR status -
 Wild-type 28 84.8 5 17.9
 Exon19 mutation 3 9.1 0 0
 Exon 21 mutation 2 6.1 0 0
Histology 0.033
 Squamous cell carcinoma 175 93.1 32 18.3
 Adenosquamous carcinoma 13 6.9 4 30.8
Smoking history 0.088a
 Non-smoker 45 23.9 12 26.7
 Current-smoker 134 71.3 23 17.2
 Unknown 9 4.8 1 11.1
CEA <0.001
 Normal 126 67.1 14 11.1
 Elevated 62 32.9 22 35.5
NSE   79    1.0
 Normal 89 47.3 17 19.1
 Elevated 99 52.7 19 19.2
Cyfra21-1 0.13
 Normal 43 22.8 11 25.5
 Elevated 145 77.2 25 17.2
SCC   80    0.68
 Normal 95 50.5 14 14.7
 Elevated 93 49.5 12 12.9
  1. Abbreviations: EGFR Epidermal growth factor receptor, BM Brain metastasis, CEA Carcinoembryonic antigen, NSE Neuron-specific enolase, Cyfra21-1 Cytokeratin 19 fragments, SCC Squamous cell carcinoma antigen
  2. apatients with unknown smoking history were excluded