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Table 1 Patient characteristics

From: Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center

Variables

No.

%

No. of BM

Incidence of BM

P value

Median age (years)

63(32-89)

 

36

19.1

 

Age

0.077

 < 60

79

42.0

20

25.3

 ≥ 60

109

58.0

16

14.7

Gender

0.002

 Male

163

86.7

27

16.6

 Female

25

13.3

9

36.0

Stage

<0.001

 I

15

7.9

1

6.7

 II

24

12.8

1

4.2

 III

96

51.1

12

12.5

 IV

53

28.2

22

41.5

T status

0.36

 T1-2

121

64.4

25

20.6

 T3-4

67

35.6

11

16.4

N status

0.85

 N0-1

65

34.5

13

20.0

 N2-3

123

65.5

23

18.6

EGFR status

-

 Wild-type

28

84.8

5

17.9

 Exon19 mutation

3

9.1

0

0

 Exon 21 mutation

2

6.1

0

0

Histology

0.033

 Squamous cell carcinoma

175

93.1

32

18.3

 Adenosquamous carcinoma

13

6.9

4

30.8

Smoking history

0.088a

 Non-smoker

45

23.9

12

26.7

 Current-smoker

134

71.3

23

17.2

 Unknown

9

4.8

1

11.1

CEA

<0.001

 Normal

126

67.1

14

11.1

 Elevated

62

32.9

22

35.5

NSE

 

79

  

1.0

 Normal

89

47.3

17

19.1

 Elevated

99

52.7

19

19.2

Cyfra21-1

0.13

 Normal

43

22.8

11

25.5

 Elevated

145

77.2

25

17.2

SCC

 

80

  

0.68

 Normal

95

50.5

14

14.7

 Elevated

93

49.5

12

12.9

  1. Abbreviations: EGFR Epidermal growth factor receptor, BM Brain metastasis, CEA Carcinoembryonic antigen, NSE Neuron-specific enolase, Cyfra21-1 Cytokeratin 19 fragments, SCC Squamous cell carcinoma antigen
  2. apatients with unknown smoking history were excluded