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Table 2 BMFS comparison according to risk factors

From: Risk factors and treatments for brain metastasis in patients with adenocarcinoma of the lung: a retrospective analysis of 373 patients

 

Univariate

Multivariate

Variables

BMFS(month)

95%CI

P value

P value

RR

95%CI

Gender

  

0.25

0.072

0.293

0.077-1.114

 Male

37

31.2-42.7

    

 Female

36

30.1-41.8

    

Age

  

0.006

0.006

0.201

0.065-0.624

  ≤ 60

32

22.9-41.0

    

  > 60

70

27.9-112.0

    

Stage

  

< 0.001

0.68

1.166

0.554-2.455

 I/II

114

47.3-180.6

    

 III/IV

27

20.7-33.2

    

T status

  

0.009

0.43

1.648

0.469-5.791

 T1-2

46

19.0-72.9

    

 T3-4

29

20.1-37.8

    

N status

  

< 0.001

0.041

2.891

1.045-7.996

 N0-1

83

31.5-134.4

    

 N2-3

25

15.5-34.4

    

EGFR status

  

0.018

0.57

1.350

0.478-3.818

 Wild-type

35

0-70.6

    

 Sensitive mutation

13

10.6-15.3

    

Histology

  

0.02

0.38

0.402

0.051-3.155

 Adenocarcinoma

35

30.9-39.0

    

 Non- Adenocarcinoma

Not reached

     

Smoking status

  

0.69

0.18

0.418

0.115-1.518

 Never

36

29.2-42.7

    

 Current

37

31.3-42.7

    
  1. Stage was not analyzed simultaneously with T/N status in multivariate analysis
  2. Abbreviations: BMFS brain-metastasis-free survival, EGFR epidermal growth factor receptor