Risk factors and treatments for brain metastasis in patients with adenocarcinoma of the lung: a retrospective analysis of 373 patients

Table 3 Characteristics of patients with BM

Variables	No.	%
Number of BM
1	97	50.8
2-3	39	20.4
> 3	55	28.8
Presence of systemic metastasis at the time of BM
Yes	161	84.3
No	30	15.7
Treatments after BM
None	14	7.3
Local therapy only	63	33.0
Local+systemic therapy	98	51.3
systemic therapy only	16	8.4
Local therapy (n = 161)
SRS	105(9)^a	65.2
WBRT	40(1)	24.8
SRS + WBRT	16(2)	10.0
Systemic therapy regimens(n = 114)
Third-generation regimens	20	17.5
Pemetrexed	19	16.7
TKIs	37	32.5
Third-generation+pemetrexed	4	3.5
Third-generation+TKIs	19	16.7
Pemetrexed+TKIs	15	13.1

Abbreviations: BM brain metatasis, RPA Recursive partitioning analysis, GPA graded prognostic assessment, WBRT whole brain radiation therapy, SRS stereotactic radiosurgery, TKIs tyrosine kinase inhibitors
^aNumber in the blanket was number of patients who received surgery for brain lesions

ISSN: 2057-4967