1. Epistaxis—spontaneous, recurrent nosebleeds | |
2. Telangiectases—multiple, at characteristic sites (lips, oral cavity, fingers, nose) | |
3. Visceral lesions—such as gastrointestinal telangiectasia (with or without bleeding), pulmonary arteriovenous fistula (AVF), hepatic AVF, cerebral AVF, spinal AVF | |
4. Family history—a first-degree relative with HHT |