Fig. 1

Flow diagram illustrating organization of nine cohorts to assemble comparative database. Diagram illustrates hierarchy organizational process used to siphon and filter data from nine independent omics studies to assemble the comparative database foundation used in this study. Information provided within each box include the model evaluated in the identified cohort, background CCM mutation(s) being assessed, omics approach used, and the associated cohort information in parentheses corresponding to numbers found in Additional file 11