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Fig. 4 | Chinese Neurosurgical Journal

Fig. 4

From: Comparative omics of CCM signaling complex (CSC)

Fig. 4

Interactome of altered genes in CCM-deficient models with three validations. A total of five genes (nodes) were matched that were identified as perturbed in three different CCM studies. For datasets, non-human genes were converted to human homologs before processing and all genes capitalized to ensure overlaps were not misidentified due to case changes. Interactomes were constructed using Cytoscape software equipped with STRING application. Interactomes illustrate affected pathways with query proteins and ten interactors being incorporated into the interactome with a false discovery rate (FDR) set to 0.4 due to the smaller number of query proteins. No post modifications were made to the layout of the interactome once generated in STRING and exported to Cytoscape. Crystal structures, if available, for identified proteins are shown within the corresponding nodes

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