Table 1 Altered genes in CCM-deficient models with two validations having documented roles in angiogenic pathways. An enrichment category was exported along with Fig. 1 that detailed altered pathways involved with the identified 152 genes. Among the exported pathways, a filter search was applied to identify all enrichment data involved with angiogenesis specifically. Information provided in the table includes the term id, number of enriched genes in each enrichment category, description of the category, genes specifically involved, false discovery rate (FDR) value, and the term name for each category (which includes GO terms if applicable)
Term id | Enriched genes | Category | Description | Enriched genes | FDR value | Term name |
|---|---|---|---|---|---|---|
94 | 19 | GO Process | Angiogenesis | MYH9|MMP2|CCL2|PPP3R1|LAMA5|PDGFRA|THBS1|COL8A1|RORA|FLT1|NOS3|MMP14|CAV1|ANXA2|FN1|EPHA2|DLL1|MMRN2|CLIC4 | 1.18E−09 | GO.0001525 |
610 | 5 | GO Process | Regulation of cell migration involved in sprouting angiogenesis | MAP2K5|THBS1|AKT3|MMRN2|ANXA1 | 3.20E−04 | GO.0090049 |
616 | 6 | GO Process | Regulation of sprouting angiogenesis | MAP2K5|THBS1|AKT3|DLL1|MMRN2|ANXA1 | 3.30E−04 | GO.1903670 |
631 | 11 | GO Process | Regulation of angiogenesis | MAP2K5|HSPB1|THBS1|AKT3|FLT1|NOS3|CDH5|EPHA2|DLL1|MMRN2|ANXA1 | 3.80E−04 | GO.0045765 |
716 | 8 | GO Process | Positive regulation of angiogenesis | HSPB1|THBS1|AKT3|FLT1|NOS3|CDH5|DLL1|ANXA1 | 9.90E−04 | GO.0045766 |
910 | 3 | GO Process | Negative regulation of cell migration involved in sprouting angiogenesis | MAP2K5|THBS1|MMRN2 | 0.0034 | GO.0090051 |
1485 | 3 | GO Process | Positive regulation of sprouting angiogenesis | AKT3|DLL1|ANXA1 | 0.0226 | GO.1903672 |
1646 | 3 | GO Process | Sprouting angiogenesis | THBS1|DLL1|MMRN2 | 0.0329 | GO.0002040 |
152 | 12 | Reference publications | (2014) PPARGamma activation but not PPARGamma haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors. | MMP2|THBS1|VWF|NGEF|ICAM1|FLT1|KIT|NOS3|CCT2|MMP14|CAV1|FN1 | 2.31E−08 | PMID.25361524 |
275 | 9 | Reference publications | (2017) Talin Modulation by a Synthetic N-Acylurea Derivative Reduces Angiogenesis in Human Endothelial Cells. | GAPDH|VWF|ICAM1|FLT1|ANXA5|NOS3|CDH5|FN1|TLN2 | 1.34E−06 | PMID.28117756 |
346 | 10 | Reference publications | (2017) Platelets and cancer angiogenesis nexus. | MMP2|THBS1|VWF|ICAM1|FLT1|KIT|ITGA2|NOS3|MMP14|FN1 | 3.18E−06 | PMID.28681240 |
352 | 8 | Reference publications | (2010) PPARalpha is essential for microparticle-induced differentiation of mouse bone marrow-derived endothelial progenitor cells and angiogenesis. | THBS1|ICAM1|FLT1|CSF1R|ANXA5|NOS3|CDH5|FN1 | 3.51E−06 | PMID.20811625 |
1596 | 5 | UniProt Keywords | Angiogenesis | MMP2|COL8A1|FLT1|EPHA2|MMRN2 | 0.0297 | KW-0037 |