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Table 1 Altered genes in CCM-deficient models with two validations having documented roles in angiogenic pathways. An enrichment category was exported along with Fig. 1 that detailed altered pathways involved with the identified 152 genes. Among the exported pathways, a filter search was applied to identify all enrichment data involved with angiogenesis specifically. Information provided in the table includes the term id, number of enriched genes in each enrichment category, description of the category, genes specifically involved, false discovery rate (FDR) value, and the term name for each category (which includes GO terms if applicable)

From: Comparative omics of CCM signaling complex (CSC)

Term idEnriched genesCategoryDescriptionEnriched genesFDR valueTerm name
9419GO ProcessAngiogenesisMYH9|MMP2|CCL2|PPP3R1|LAMA5|PDGFRA|THBS1|COL8A1|RORA|FLT1|NOS3|MMP14|CAV1|ANXA2|FN1|EPHA2|DLL1|MMRN2|CLIC41.18E−09GO.0001525
6105GO ProcessRegulation of cell migration involved in sprouting angiogenesisMAP2K5|THBS1|AKT3|MMRN2|ANXA13.20E−04GO.0090049
6166GO ProcessRegulation of sprouting angiogenesisMAP2K5|THBS1|AKT3|DLL1|MMRN2|ANXA13.30E−04GO.1903670
63111GO ProcessRegulation of angiogenesisMAP2K5|HSPB1|THBS1|AKT3|FLT1|NOS3|CDH5|EPHA2|DLL1|MMRN2|ANXA13.80E−04GO.0045765
7168GO ProcessPositive regulation of angiogenesisHSPB1|THBS1|AKT3|FLT1|NOS3|CDH5|DLL1|ANXA19.90E−04GO.0045766
9103GO ProcessNegative regulation of cell migration involved in sprouting angiogenesisMAP2K5|THBS1|MMRN20.0034GO.0090051
14853GO ProcessPositive regulation of sprouting angiogenesisAKT3|DLL1|ANXA10.0226GO.1903672
16463GO ProcessSprouting angiogenesisTHBS1|DLL1|MMRN20.0329GO.0002040
15212Reference publications(2014) PPARGamma activation but not PPARGamma haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors.MMP2|THBS1|VWF|NGEF|ICAM1|FLT1|KIT|NOS3|CCT2|MMP14|CAV1|FN12.31E−08PMID.25361524
2759Reference publications(2017) Talin Modulation by a Synthetic N-Acylurea Derivative Reduces Angiogenesis in Human Endothelial Cells.GAPDH|VWF|ICAM1|FLT1|ANXA5|NOS3|CDH5|FN1|TLN21.34E−06PMID.28117756
34610Reference publications(2017) Platelets and cancer angiogenesis nexus.MMP2|THBS1|VWF|ICAM1|FLT1|KIT|ITGA2|NOS3|MMP14|FN13.18E−06PMID.28681240
3528Reference publications(2010) PPARalpha is essential for microparticle-induced differentiation of mouse bone marrow-derived endothelial progenitor cells and angiogenesis.THBS1|ICAM1|FLT1|CSF1R|ANXA5|NOS3|CDH5|FN13.51E−06PMID.20811625
15965UniProt KeywordsAngiogenesisMMP2|COL8A1|FLT1|EPHA2|MMRN20.0297KW-0037