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Table 2 Differential proteins identified in urine samples before and after tumor resection in glioma patients

From: Urinary biomarker discovery in gliomas using mass spectrometry-based clinical proteomics

UniprotDescriptionFCaPRefb
P35443Thrombospondin-4 (TSP4)#↓ 13.00.024 
P6160410 kDa heat shock protein, mitochondrial (CH10)#↑ 8.50.018 
Q8IZF2Adhesion G protein-coupled receptor F5 (AGRF5)#↑ 7.00.018 
P20073Annexin A7 (ANXA7)↑ 6.00.034[18]
P40926Malate dehydrogenase, mitochondrial (MDHM)#↑ 4.20.007 
P02511Alpha-crystallin B chain (CRYAB)↑ 3.90.033[19]
P09417Dihydropteridine reductase (DHPR)↑ 2.50.039[20]
O43451Maltase-glucoamylase, intestinal (MGA)#↑ 2.40.010 
P13489Ribonuclease inhibitor (RINI)#↓ 2.40.049 
Q9H3G5Probable serine carboxypeptidase (CPVL)#↑ 2.30.015 
P13473Lysosome-associated membrane glycoprotein 2 (LAMP2)#↑ 2.20.012[21]
Q92820Gamma-glutamyl hydrolase (GGH)↑ 2.00.015 
Q07075Glutamyl aminopeptidase (AMPE)#↑ 2.00.046[20]
Q5ZPR3CD276 antigen (CD276)#↑ 1.90.042[22]
O96009Napsin-A (NAPSA)↑ 1.90.005 
Q13510Acid ceramidase (ASAH1)#↑ 1.90.001[23]
Q9BQ51Programmed cell death 1 ligand 2 (PD1L2)↑ 1.90.004[24, 25]
P11279Lysosome-associated membrane glycoprotein 1 (LAMP1)#↑ 1.80.028[20]
Q13228Selenium-binding protein 1 (SBP1)#↑ 1.70.035[26]
P42785Lysosomal Pro-X carboxypeptidase (PCP)#↑ 1.60.012 
P08236Beta-glucuronidase (BGLR)↑ 1.60.022[27]
P15144Aminopeptidase N (AMPN)#↑ 1.60.043[28]
P01833Polymeric immunoglobulin receptor (PIGR)↑ 1.50.043[29]
Q96PD5N-acetylmuramoyl-L-alanine amidase (PGRP2) #↓ 1.50.043 
P07339Cathepsin D (CTSD)↑ 1.50.043[30]
P13688Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)#↑ ∞0.052[31]
P27797Calreticulin (CALR)↓ ∞0.068[32]
  1. #Differential urinary proteins from both proteome analyses are in bold
  2. aChange trends of proteins after tumor resection
  3. bProteins associated with gliomas in previous studies