Table 1 Summary of previous studies and recommended level according to the Oxford Centre for Evidence-based Medicine Levels of Evidence

Wijnenga et al. [13]

IDH, 1p/19q

2

228

IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary

3b

Patel et al. [12]

IDH

2

74

IDHmt: no correlation; IDHwt: the more the better

3b

Delev et al. [14]

IDH, 1p/19q

2 and 3

299

IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary; IDHwt: the more the better

3b

Ding et al. [15]

IDH, 1p/19q

2, 3 and 4

1600

IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary;

3b

Koriyama et al. [5]

IDH, ATRX, p53

2 and 3

–

IDHmt, loss of ATRX nuclear expression and p53 high expression: GTR; IDHmt, ATRX nuclear expression and p53 low expression: functional region > 90% resection, non-functional region-GTR; IDHwt: functional region-GTR, non-functional region-supra-total resection.

5

Kawaguchi et al. [6]

IDH, 1p/19q

3

124

IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary; IDHwt: GTR unnecessary

3b

Beiko et al. [11]

IDH

3 and 4

335

IDHmt, 1p/19q non-codel: enhancing and non-enhancing tumor resection; IDHwt: enhancing tumor resection

3b

Sharma et al. [16]

MGMT

4

233

MGMT promoter methylation or unmethylation: enhancing tumor resection ≥ 86%

3b

Sayeed et al. [17]

MGMT

4

63

MGMT promoter methylation: EOR ≥ 95%

3b

Gessler et al. [18]

IDH, MGMT

4

175

IDHwt: GTR, no matter what MGMT promoter expression

3b

Fontana et al. [19]

EGFR

GBM cell line

–

EGFRvIII alone or with EGFR overexpression decrease 5-ALA-induced fluorescence

5

Yue et al. [20]

EGFR v III

GBM bearing mice

–

EGFRvIII nanoprobe assists in determining tumor boundaries

5

Munthe et al. [21]

CD133

2, 3, and 4

26

CD133 expressed in tumor margin cells

5

Cordier et al. [22]

1p/19q

2

200

Higher EOR associated with 1p/19q non- or single deletion

3b

Paldor et al. [23]

Ki-67

4

223

GBM in the frontal lobe show higher Ki-67 index, early treatment is recommended

3b