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Table 1 Summary of previous studies and recommended level according to the Oxford Centre for Evidence-based Medicine Levels of Evidence

From: Role of molecular biomarkers in glioma resection: a systematic review

Authors [reference] Molecular marker WHO grade Patient number Surgical guidance Level
Wijnenga et al. [13] IDH, 1p/19q 2 228 IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary 3b
Patel et al. [12] IDH 2 74 IDHmt: no correlation; IDHwt: the more the better 3b
Delev et al. [14] IDH, 1p/19q 2 and 3 299 IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary; IDHwt: the more the better 3b
Ding et al. [15] IDH, 1p/19q 2, 3 and 4 1600 IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary; 3b
Koriyama et al. [5] IDH, ATRX, p53 2 and 3 IDHmt, loss of ATRX nuclear expression and p53 high expression: GTR; IDHmt, ATRX nuclear expression and p53 low expression: functional region > 90% resection, non-functional region-GTR; IDHwt: functional region-GTR, non-functional region-supra-total resection. 5
Kawaguchi et al. [6] IDH, 1p/19q 3 124 IDHmt, 1p/19q non-codel: GTR; IDHmt, 1p/19q codel: GTR unnecessary; IDHwt: GTR unnecessary 3b
Beiko et al. [11] IDH 3 and 4 335 IDHmt, 1p/19q non-codel: enhancing and non-enhancing tumor resection; IDHwt: enhancing tumor resection 3b
Sharma et al. [16] MGMT 4 233 MGMT promoter methylation or unmethylation: enhancing tumor resection ≥ 86% 3b
Sayeed et al. [17] MGMT 4 63 MGMT promoter methylation: EOR ≥ 95% 3b
Gessler et al. [18] IDH, MGMT 4 175 IDHwt: GTR, no matter what MGMT promoter expression 3b
Fontana et al. [19] EGFR GBM cell line EGFRvIII alone or with EGFR overexpression decrease 5-ALA-induced fluorescence 5
Yue et al. [20] EGFR v III GBM bearing mice EGFRvIII nanoprobe assists in determining tumor boundaries 5
Munthe et al. [21] CD133 2, 3, and 4 26 CD133 expressed in tumor margin cells 5
Cordier et al. [22] 1p/19q 2 200 Higher EOR associated with 1p/19q non- or single deletion 3b
Paldor et al. [23] Ki-67 4 223 GBM in the frontal lobe show higher Ki-67 index, early treatment is recommended 3b
  1. Abbreviations: EOR extent of resection, GBM glioblastoma, GTR gross total resection, IDH isocitrate dehydrogenase, IDHmt IDH mutation, IDHwt IDH wild-type, 1p/19q codel 1p/19q codeletion, 1p/19q non-codel 1p/19q non-codeletion, MGMT O6-methylguanine-DNA methyltransferase