Fig. 2
From: Diffuse intrinsic pontine glioma: current insights and future directions
Representative histology of pediatric DIPG. a Hematoxylin & eosin stain of pediatric DIPG acquired post-mortem, note diffusely infiltrative tumor cells amidst a background matrix of neuropil. b Immunohistochemical staining of the same sample using antibody directed to the H3K27M epitope. The sample is strongly positive. c Immunohistochemical staining of mutant p53, a common co-occurring mutation in DIPG. Note sparser staining than H3K27M in panel b