Fig. 3

Drug targets and treatments of pediatric DIPG. DIPGs are characterized by the K27M mutation that occurs in histone H3. Therapies which target the epigenome including histone deacetylase inhibitors such as panobinostat (a) and histone demethylase inhibitors such as GSK-J4 (b) have been demonstrated to be effective in clinical trials. Furthermore, residual PRC2 activity has been shown to be required for proliferation and thus EZH2 inhibitors such as tazemetostat (c) has been effective in treating these tumors