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Table 1 Uni- and multivariate Cox regression analysis of the risk score and clinicopathologic factors for OS in TCGA and CGGA databases

From: A novel gene signature based on five immune checkpoint genes predicts the survival of glioma

Variable Univariate Cox   Multivariate Cox  
P value HR 95% CI for HR P value HR 95% CI for HR
Gender 0.350 1.145 0.862-1.519    
Age <0.0001 1.073 1.061-1.084 <0.0001 1.057 1.043-1.072
IDH 1 status <0.0001 0.163 0.121-0.219 0.085 0.726 0.504-1.045
MGMT promoter status <0.0001 0.337 0.247-0.461 0.067 0.712 0.494-1.025
Grade <0.0001 4.794 3.798-6.051 <0.0001 2.071 1.538-2.788
RiskScore <0.0001 3.182 2.682-3.777 <0.0001 2.050 1.620-2.593
Variable Univariate Cox   Multivariate Cox
P value HR 95% CI for HR P value HR 95% CI for HR
Gender 0.345 1.181 0.837-1.666    
Age <0.0001 1.038 1.023-1.054 0.368 1.007 0.991-1.023
IDH 1 status <0.0001 0.256 0.178-0.368 0.165 0.687 0.405-1.167
MGMT promoter status <0.0001 0.516 0.362-0.736 0.077 0.706 0.480-1.039
Grade <0.0001 3.477 2.716-4.452 <0.0001 2.513 1.850-3.415
Chemotherapy 0.125 1.151 0.962-1.378    
Radiotherapy 0.688 0.945 0.718-1.244    
RiskScore <0.0001 >10 >10 0.025 >10 >10