Exclusion criteria: (1) patients had cerebrovascular diseases, e.g., intracranial aneurysm or vascular malformation, and intracranial tumors, which were associated with hemorrhage; (2) hemorrhagic transformation of cerebral infarction; (3) hemorrhage caused by venous thrombosis; (4) patients with severe coagulation disorder, e.g., hemophilia; (5) patients with coagulation dysfunction caused by malignant tumor, hypohepatia, renal dysfunction, thrombocytopenia, coagulation diseases, and so on; (6) patients receiving other anticoagulation medications (vitamin K antagonist and new oral anticoagulants); (7) patients not on LOAPT who receive conservative treatment; (8) the patients who died before or on arriving at the hospital and within a short period (6 h) after admission. |