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Table 2 Clinical characteristics of CNS disease in SCNSL patients

From: Treatment of secondary central nervous system involvement in systemic aggressive B cell lymphoma using R-MIADD chemotherapy: a single-center study

CNS characteristics N %
CNS age
 Median, range 59, 20–76  
 ≤ 60 10 52.6
 > 60 9 47.4
Initial symptoms
 Headache 5 26.3
 Dizziness 5 26.3
 Blurred version 2 10.5
 Limb weakness 2 10.5
 Seizure 1 5.3
 Somnolence 1 5.3
 Focal neurological deficits 3 15.8
ECOG-PS
 ≤ 1 6 31.6
 > 1 13 68.4
Type of CNS relapse
 New disease 10 52.6
 Relapse 4 21.1
 CNS only 3  
 Combined CNS and systemic disease 1  
 Refractory 5 26.3
Multiplicity
 Single 6 31.6
 Multiple 13 68.4
Enhancement
 Homogenous 11 57.9
 Patchy 7 36.8
 None 1 5.3
Location of disease
 White matter 16 84.2
 Cerebellum 3 74.2
 Brain stem 3 15.8
 Deep gray matter 10 47.4
Diagnosis approaches
 Biopsy 10 52.6
 Surgery section 4 21.1
 Enhanced MRI 4 21.1
 CSF cytology 1 5.3
Histology at relapse
 ABC 10 52.6
 GCB 4 21.1
 NA 5 26.3
  1. ABC activated B cell, GCB germinal center B cell, NA not available