Table 2 Clinical characteristics of CNS disease in SCNSL patients
CNS characteristics | N | % |
|---|---|---|
CNS age | ||
Median, range | 59, 20–76 | |
≤ 60 | 10 | 52.6 |
> 60 | 9 | 47.4 |
Initial symptoms | ||
Headache | 5 | 26.3 |
Dizziness | 5 | 26.3 |
Blurred version | 2 | 10.5 |
Limb weakness | 2 | 10.5 |
Seizure | 1 | 5.3 |
Somnolence | 1 | 5.3 |
Focal neurological deficits | 3 | 15.8 |
ECOG-PS | ||
≤ 1 | 6 | 31.6 |
> 1 | 13 | 68.4 |
Type of CNS relapse | ||
New disease | 10 | 52.6 |
Relapse | 4 | 21.1 |
CNS only | 3 | |
Combined CNS and systemic disease | 1 | |
Refractory | 5 | 26.3 |
Multiplicity | ||
Single | 6 | 31.6 |
Multiple | 13 | 68.4 |
Enhancement | ||
Homogenous | 11 | 57.9 |
Patchy | 7 | 36.8 |
None | 1 | 5.3 |
Location of disease | ||
White matter | 16 | 84.2 |
Cerebellum | 3 | 74.2 |
Brain stem | 3 | 15.8 |
Deep gray matter | 10 | 47.4 |
Diagnosis approaches | ||
Biopsy | 10 | 52.6 |
Surgery section | 4 | 21.1 |
Enhanced MRI | 4 | 21.1 |
CSF cytology | 1 | 5.3 |
Histology at relapse | ||
ABC | 10 | 52.6 |
GCB | 4 | 21.1 |
NA | 5 | 26.3 |