Long noncoding RNA SNHG12 is a potential diagnostic and prognostic biomarker in various tumors

Table 2 Subgroup and meta-regression analysis of HRs in different cancer type, cut-off, sample size, and quality score subgroup

Subgroup analysis	No. of studies	No. of patients	Pool HR (95% CI)		Weight	Heterogeneity random
Subgroup analysis	No. of studies	No. of patients	Fixed	Random	Weight	I² (%)	p value
Overall survival	9	577	2.17 [1.69, 2.80]	2.17 [1.69, 2.80]	100%	0	0.99
Cancer type
Digestive system	4	222	2.12 [1.43, 3.15]	2.12 [1.43, 3.15]	41.20%	0	0.81
Respiratory system	2	169	1.94 [1.15, 3.28]	1.94 [1.15, 3.28]	23.30%	0	0.88
Reproductive system	1	76	2.40 [1.12, 5.15]	2.40 [1.12, 5.15]	11.00%	-	-
Nervous system	1	79	2.41 [1.17, 4.97]	2.41 [1.17, 4.97]	12.30%	-	-
Locomotor system	1	31	2.41 [1.17, 4.97]	2.41 [1.17, 4.97]	12.30%	-	-
Cut-off
Others	3	161	2.30 [1.51, 3.51]	2.30 [1.51, 3.51]	36.20%	0	0.97
Median	6	416	2.10 [1.53, 2.89]	2.10 [1.53, 2.89]	63.80%	0	0.95
Quality score
Score < 80	3	131	1.71 [0.88, 3.32]	1.71 [0.88, 3.32]	16.50%	0	0.9
Score ≥ 80	6	446	2.23 [1.66, 3.00]	2.23 [1.66, 3.00]	83.50%	0	0.99
Sample size
Size < 60	3	133	2.23 [1.23, 4.03]	2.23 [1.23, 4.03]	20.6%	0	1
Size ≥ 60	6	444	2.12 [1.56, 2.86]	2.12 [1.56, 2.86]	79.4%	0	0.94

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