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Table 2 Subgroup and meta-regression analysis of HRs in different cancer type, cut-off, sample size, and quality score subgroup

From: Long noncoding RNA SNHG12 is a potential diagnostic and prognostic biomarker in various tumors

Subgroup analysis No. of studies No. of patients Pool HR (95% CI) Weight Heterogeneity random
Fixed Random I2 (%) p value
Overall survival 9 577 2.17 [1.69, 2.80] 2.17 [1.69, 2.80] 100% 0 0.99
Cancer type
 Digestive system 4 222 2.12 [1.43, 3.15] 2.12 [1.43, 3.15] 41.20% 0 0.81
 Respiratory system 2 169 1.94 [1.15, 3.28] 1.94 [1.15, 3.28] 23.30% 0 0.88
 Reproductive system 1 76 2.40 [1.12, 5.15] 2.40 [1.12, 5.15] 11.00% - -
 Nervous system 1 79 2.41 [1.17, 4.97] 2.41 [1.17, 4.97] 12.30% - -
 Locomotor system 1 31 2.41 [1.17, 4.97] 2.41 [1.17, 4.97] 12.30% - -
Cut-off
 Others 3 161 2.30 [1.51, 3.51] 2.30 [1.51, 3.51] 36.20% 0 0.97
 Median 6 416 2.10 [1.53, 2.89] 2.10 [1.53, 2.89] 63.80% 0 0.95
Quality score
 Score < 80 3 131 1.71 [0.88, 3.32] 1.71 [0.88, 3.32] 16.50% 0 0.9
 Score ≥ 80 6 446 2.23 [1.66, 3.00] 2.23 [1.66, 3.00] 83.50% 0 0.99
Sample size
 Size < 60 3 133 2.23 [1.23, 4.03] 2.23 [1.23, 4.03] 20.6% 0 1
 Size ≥ 60 6 444 2.12 [1.56, 2.86] 2.12 [1.56, 2.86] 79.4% 0 0.94