Long noncoding RNA SNHG12 is a potential diagnostic and prognostic biomarker in various tumors

Table 4 The subgroup of the relationship and heterogeneity between high SNHG12 expression and lymphatic metastasis

Subgroup analysis	No. of studies	No. of patients	Pool HR (95% CI)		Weight	Heterogeneity random
Subgroup analysis	No. of studies	No. of patients	Fixed	Random	Weight	I² (%)	p value
ORs of lymphatic metastasis subgroup	5	421	2.60 [1.72, 3.91]	2.66 [1.65, 4.29]	100%	22	0.28
Cancer type
Digestive system	2	114	5.60 [2.44, 12.89]	5.57 [2.41, 12.86]	27.70%	0	0.62
Respiratory system	1	129	1.62 [0.76, 3.45]	1.62 [0.76, 3.45]	27.80%	-	-
Reproductive system	2	178	2.29 [1.23, 4.26]	2.29 [1.23, 4.26]	44.50%	0	0.92
Cut-off
Others	2	130	3.38 [1.60, 7.15]	3.65 [1.16, 11.44]	31.70%	51	0.15
Median	3	291	2.31 [1.41, 3.78]	2.35 [1.35, 4.10]	68.30%	22	0.28
Sample size
Size < 60	2	156	3.29 [1.66, 6.52]	3.65 [1.25, 10.65]	36.30%	50	0.16
Size ≥ 60	3	265	2.27 [1.36, 3.79]	2.31 [1.29, 4.14]	63.70%	19	0.29
Quality scores
Score < 80	3	238	2.73 [1.59, 4.67]	2.73 [1.59, 4.68]	60.50%	0	0.54
Score ≥ 80	2	183	2.42 [1.28, 4.57]	3.09 [0.72, 13.17]	39.50%	73	0.05

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