|
Patient
|
DBS parameters
|
MDS-UPDRS scores f
|
Brain global efficiency g
|
|---|
| |
Electrode contact,
| |
Optimal frequency
| | | | |
|---|
|
DBS machines a
|
voltage, and
|
Frequencies
|
determined by
|
S1
|
S2
|
Average
|
GE
|
|---|
| |
impulse duration a,b
| |
the doctors c,d,e
| | | | |
|---|
|
P1
|
Left hemisphere:
| | | | | | |
| |
(10, 2.9V, 90 μs)
|
125Hz
|
125 Hz
|
1
|
1
|
1
|
2.8253
|
| |
(11, 2.7V, 60 μs)
|
100Hz
| |
2
|
1
|
1.5
|
2.4961
|
|
Medtronic
|
Right hemisphere:
|
80Hz
| |
2
|
2
|
2
|
2.3683
|
| |
(2, 2.7V, 60 μs)
|
60Hz
| |
2
|
2
|
2
|
1.0446
|
| |
(3, 2.5V, 60 μs)
| | | | | | |
|
P2
|
Left hemisphere:
|
130Hz
|
130 Hz
|
1
|
1
|
1
|
3.4236
|
| |
(6, 2.7V, 60 μs)
|
160Hz
| |
1
|
1
|
1
|
2.8045
|
|
PINS
|
Right hemisphere:
|
185Hz
| |
1
|
1
|
1
|
2.7523
|
| |
(2, 2.7V, 60 μs)
|
100Hz
| |
1
|
1
|
1
|
2.5749
|
|
P3
|
Left hemisphere:
| | | | | | |
| |
(10, 2V, 80 μs)
|
100Hz
|
100 Hz
|
1
|
1
|
1
|
4.0123
|
| |
(8, 2V, 60 μs)
|
80Hz
| |
1
|
1
|
1
|
3.3139
|
|
Medtronic
|
Right hemisphere:
|
60Hz
| |
1
|
1
|
1
|
2.3944
|
| |
(2, 1.7V, 60 μs)
|
125Hz
| |
1
|
1
|
1
|
1.7739
|
| |
(3, 1.7V, 60 μs)
| | | | | | |
|
P4
|
Left hemisphere:
|
160Hz
|
160 Hz
|
1
|
1
|
1
|
3.3366
|
| |
(9, 1.8V, 60 μs)
|
130Hz
| |
1
|
1
|
1
|
2.9649
|
|
Medtronic
|
Right hemisphere:
|
60Hz
| |
2
|
1
|
1.5
|
2.7418
|
| |
(3, 2.5V, 60 μs)
|
80Hz
| |
2
|
1
|
1.5
|
2.3951
|
|
P5
|
Left hemisphere:
|
130Hz
|
130 Hz
|
1
|
1
|
1
|
3.5287
|
| |
(4, 3V, 60 μs)
|
80Hz
| |
1
|
1
|
1
|
3.1407
|
|
PINS
|
Right hemisphere:
|
60Hz
| |
1
|
1
|
1
|
2.7492
|
| |
(6, 3V, 60 μs)
|
160Hz
| |
1
|
1
|
1
|
2.5838
|
- aDefinition of electrode contact points depends on the DBS machines
- bThe location and number of stimulation points were determined by the doctors
- cThese frequencies were the doctors’ on-site decision in DBS programming and actually used for treatment
- dThe optimal frequencies were determined by doctors considering the rigidity, tremor, gait and patients’ feeling. In the experiments, the optimal frequencies determined by doctors were consistent the frequencies that patients felt the most comfortable
- eOne-month follow-up after DBS programming reported that all the five patients were satisfied with the DBS treatment, and no adverse effect or feelings was reported or noticed by the patients, their families, or doctors
- fThe MDS-UPDRS scores were rated by two qualified and experienced doctors, based on the recorded videos on patient performance during DBS programming
- c,f,gThe DBS programming decision, MDS-UPDRS ratings, and GE analysis were conducted independently from each other, and the relative results were not revealed to the personnel performing other analysis until the entire study was accomplished
