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Table 3 Comparison of brain efficiency with clinical assessments including the on-site DBS programming decisions and post independent MDS-UPDRS ratings based on the recorded videos

From: Quantified assessment of deep brain stimulation on Parkinson’s patients with task fNIRS measurements and functional connectivity analysis: a pilot study

Patient

DBS parameters

MDS-UPDRS scores f

Brain global efficiency g

 

Electrode contact,

 

Optimal frequency

    

DBS machines a

voltage, and

Frequencies

determined by

S1

S2

Average

GE

 

impulse duration a,b

 

the doctors c,d,e

    

P1

Left hemisphere:

      
 

(10, 2.9V, 90 μs)

125Hz

125 Hz

1

1

1

2.8253

 

(11, 2.7V, 60 μs)

100Hz

 

2

1

1.5

2.4961

Medtronic

Right hemisphere:

80Hz

 

2

2

2

2.3683

 

(2, 2.7V, 60 μs)

60Hz

 

2

2

2

1.0446

 

(3, 2.5V, 60 μs)

      

P2

Left hemisphere:

130Hz

130 Hz

1

1

1

3.4236

 

(6, 2.7V, 60 μs)

160Hz

 

1

1

1

2.8045

PINS

Right hemisphere:

185Hz

 

1

1

1

2.7523

 

(2, 2.7V, 60 μs)

100Hz

 

1

1

1

2.5749

P3

Left hemisphere:

      
 

(10, 2V, 80 μs)

100Hz

100 Hz

1

1

1

4.0123

 

(8, 2V, 60 μs)

80Hz

 

1

1

1

3.3139

Medtronic

Right hemisphere:

60Hz

 

1

1

1

2.3944

 

(2, 1.7V, 60 μs)

125Hz

 

1

1

1

1.7739

 

(3, 1.7V, 60 μs)

      

P4

Left hemisphere:

160Hz

160 Hz

1

1

1

3.3366

 

(9, 1.8V, 60 μs)

130Hz

 

1

1

1

2.9649

Medtronic

Right hemisphere:

60Hz

 

2

1

1.5

2.7418

 

(3, 2.5V, 60 μs)

80Hz

 

2

1

1.5

2.3951

P5

Left hemisphere:

130Hz

130 Hz

1

1

1

3.5287

 

(4, 3V, 60 μs)

80Hz

 

1

1

1

3.1407

PINS

Right hemisphere:

60Hz

 

1

1

1

2.7492

 

(6, 3V, 60 μs)

160Hz

 

1

1

1

2.5838

  1. aDefinition of electrode contact points depends on the DBS machines
  2. bThe location and number of stimulation points were determined by the doctors
  3. cThese frequencies were the doctors’ on-site decision in DBS programming and actually used for treatment
  4. dThe optimal frequencies were determined by doctors considering the rigidity, tremor, gait and patients’ feeling. In the experiments, the optimal frequencies determined by doctors were consistent the frequencies that patients felt the most comfortable
  5. eOne-month follow-up after DBS programming reported that all the five patients were satisfied with the DBS treatment, and no adverse effect or feelings was reported or noticed by the patients, their families, or doctors
  6. fThe MDS-UPDRS scores were rated by two qualified and experienced doctors, based on the recorded videos on patient performance during DBS programming
  7. c,f,gThe DBS programming decision, MDS-UPDRS ratings, and GE analysis were conducted independently from each other, and the relative results were not revealed to the personnel performing other analysis until the entire study was accomplished