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Table 3 Comparison of brain efficiency with clinical assessments including the on-site DBS programming decisions and post independent MDS-UPDRS ratings based on the recorded videos

From: Quantified assessment of deep brain stimulation on Parkinson’s patients with task fNIRS measurements and functional connectivity analysis: a pilot study

Patient DBS parameters MDS-UPDRS scores f Brain global efficiency g
  Electrode contact,   Optimal frequency     
DBS machines a voltage, and Frequencies determined by S1 S2 Average GE
  impulse duration a,b   the doctors c,d,e     
P1 Left hemisphere:       
  (10, 2.9V, 90 μs) 125Hz 125 Hz 1 1 1 2.8253
  (11, 2.7V, 60 μs) 100Hz   2 1 1.5 2.4961
Medtronic Right hemisphere: 80Hz   2 2 2 2.3683
  (2, 2.7V, 60 μs) 60Hz   2 2 2 1.0446
  (3, 2.5V, 60 μs)       
P2 Left hemisphere: 130Hz 130 Hz 1 1 1 3.4236
  (6, 2.7V, 60 μs) 160Hz   1 1 1 2.8045
PINS Right hemisphere: 185Hz   1 1 1 2.7523
  (2, 2.7V, 60 μs) 100Hz   1 1 1 2.5749
P3 Left hemisphere:       
  (10, 2V, 80 μs) 100Hz 100 Hz 1 1 1 4.0123
  (8, 2V, 60 μs) 80Hz   1 1 1 3.3139
Medtronic Right hemisphere: 60Hz   1 1 1 2.3944
  (2, 1.7V, 60 μs) 125Hz   1 1 1 1.7739
  (3, 1.7V, 60 μs)       
P4 Left hemisphere: 160Hz 160 Hz 1 1 1 3.3366
  (9, 1.8V, 60 μs) 130Hz   1 1 1 2.9649
Medtronic Right hemisphere: 60Hz   2 1 1.5 2.7418
  (3, 2.5V, 60 μs) 80Hz   2 1 1.5 2.3951
P5 Left hemisphere: 130Hz 130 Hz 1 1 1 3.5287
  (4, 3V, 60 μs) 80Hz   1 1 1 3.1407
PINS Right hemisphere: 60Hz   1 1 1 2.7492
  (6, 3V, 60 μs) 160Hz   1 1 1 2.5838
  1. aDefinition of electrode contact points depends on the DBS machines
  2. bThe location and number of stimulation points were determined by the doctors
  3. cThese frequencies were the doctors’ on-site decision in DBS programming and actually used for treatment
  4. dThe optimal frequencies were determined by doctors considering the rigidity, tremor, gait and patients’ feeling. In the experiments, the optimal frequencies determined by doctors were consistent the frequencies that patients felt the most comfortable
  5. eOne-month follow-up after DBS programming reported that all the five patients were satisfied with the DBS treatment, and no adverse effect or feelings was reported or noticed by the patients, their families, or doctors
  6. fThe MDS-UPDRS scores were rated by two qualified and experienced doctors, based on the recorded videos on patient performance during DBS programming
  7. c,f,gThe DBS programming decision, MDS-UPDRS ratings, and GE analysis were conducted independently from each other, and the relative results were not revealed to the personnel performing other analysis until the entire study was accomplished