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Table 5 Factor associated unfavorable outcome (mRS 3-6) at postoperative 6 months in patients with ruptured anterior communicating artery aneurysm by binary logistic regression analysis (n = 141)

From: Surgical outcomes of patients after treatment of ruptured anterior communicating artery aneurysms: “real-world” evidence from southern Thailand

  Univariable analysis Multivariable analysisa
Factor Odds ratio (95% CI) P value Odds ratio (95% CI) P value
Female 1.49 (0.68–3.25) 0.320   
Age ≥ 60 4.17 (1.78–9.77) 0.001   
Hypertension 3.35 (1.49–7.55) 0.004   
Presenting symptom     
 Headache 0.67 (0.30–1.54) 0.360   
 Vomiting 1.31 (0.60–2.88) 0.500   
 Alteration of consciousness 4.15 (1.66–10.38) 0.002   
 Seizure 0.54 (0.17–1.70) 0.290   
 Hemiparesis 2.58 (0.76–8.74) 0.130   
 Deterioration prior surgery 2.56 (0.95–6.94) 0.065   
HH grades 3–5 2.38 (1.06–5.35) 0.036   
WFNS grades 3–5 2.45 (1.08–5.57) 0.033   
Aneurysm characteristics     
 Neck width ≥ 4 mm 0.48 (0.15–1.51) 0.210   
 DN ratio ≥ 2 0.43 (0.20–0.96) 0.039   
 A1 hypoplasia 7.00 (2.51–19.50) < 0.001 8.90 (2.82–28.04) < 0.001
 Multiple aneurysm 3.04 (0.86–10.68) 0.084   
Pre ICH 1.03 (0.44–2.42) 0.940   
Pre HCP 2.97 (0.53–16.49) 0.220   
Pre IVH 15.71 (4.51–54.75) < 0.001 19.66 (5.10–75.80) < 0.001
Delayed surgery 1.14 (0.50–2.61) 0.760   
Multiple clips (≥ 2) 1.71 (0.75–3.90) 0.201   
Intraoperative rupture 0.96 (0.32–2.84) 0.940   
Operative time ≥ 5 h 1.06 (0.41–2.74) 0.900   
Estimated blood loss ≥ 600 mL 1.39 (0.61–3.13) 0.430   
Complications     
 Intracerebral hemorrhage 10.30 (1.03–102.67) 0.047   
 Neurological worse 2.28 (0.99–5.23) 0.053   
 Symptomatic vasospasm 2.34 (0.97–5.63) 0.057   
 Cerebral infarction 2.96 (1.33–6.62) 0.008 3.21 (1.16–8.88) 0.025
 Infectious complications 5.28 (2.28–12.23) < 0.001   
  1. aValue shows only the significant values in final model of multivariable logistic regression with backward elimination (likelihood ratio) method
  2. CI, confidence interval; DN, dome-to-neck; HH, Hunt and Hess grade; mRS, modified Rankin scale; Pre ICH, preoperative intracerebral hemorrhage; Pre IVH, preoperative intraventricular hemorrhage; WFNS, World Federation Neurological Society