Fig. 2
From: Underlying mechanism of hemodynamics and intracranial aneurysm
Hemodynamic induced inflammatory process in intracranial aneurysm development. The irregular blood flow triggers the inflammation in the artery, and the inflammatory cytokines including IL-1β, MMP-2, MMP-9, MAPK, PDGH, NF-κB, and NO collaboratively contribute to the development of intracranial aneurysm