Table 1 Basic characteristics of the included studies
Study name | I/A/Ga | Interventionb | No. | Male/female | Meanage/y | Biochemical cure ratec | Recurrent rated | Duration 1 | Duration 2 | Duration 3 | Study type |
|---|---|---|---|---|---|---|---|---|---|---|---|
Adam 2013 | mixed_p | endoscopic_s | 17 | NA | NA | 8/17 | NA | 40 | Â | Â | Case-series |
Akira 2006 | mixed_p | mixed_s | 13 | 3/10 | NA | NA | NA | NA | Â | Â | Case-series |
Albert 1992 | 0/29/0 | BRC | 29 | 14/15 | NA | NA | NA | NA | NA | NA | Non-RCT |
Alessandro 2013 | mixed_p | CAB | 43 | 8/35 | 33.65 | 24/43 | NA | NA | 12 | NA | Case-series |
Alexander 2018 | 60/0/0 | endoscopic_s | 60 | 10/50 | 33.5 | 40/60 | NA | 37 | Â | Â | Non-RCT |
Amir 2007 | 12/13/0 | endoscopic_s | 25 | NA | NA | 21/25 | NA | 19 | Â | Â | Case-series |
Amit 2015 | 0/71/0 | CAB | 71 | 71/0 | 44.7 | 51/71 | NA | 80.3 | NA | NA | Case-series |
Andreja 2012 | 39/22/0 | endoscopic_s | 61 | NA | NA | 54/61 | NA | NA | Â | Â | Case-series |
Annamaria1 2004 | mixed_p | CAB | 20 | 20/0 | 34 | 20/20 | NA | NA | NA | NA | Non-RCT |
Annamaria2 2004 | 10/41/0 | CAB | 51 | 51/0 | 32.9 | 39/51 | NA | 24 | Â | Â | Non-RCT |
Annamaria 2007 | 115/79/0 | CAB | 194 | NA | NA | NA | 81/194 | 68.6 | 42.6 | 45.8 | Case-series |
Annamaria 1997 | 8/19/0 | mixed_DA | 27 | NA | NA | 23/27 | NA | NA | NA | NA | Case-series |
Annamaria 2000 | 0/45/0 | mixed_DA | 45 | 17/45 | NA | 40/45 | NA | NA | NA | NA | Non-RCT |
Antonell 2001 | 44/28/0 | mixed_DA | 188 | NA | NA | 138/188 | NA | 8.3 | NA | NA | Non-RCT |
Antonio 2007 | mixed_p | mixed_s | 65 | 20/45 | 36 | 42/65 | 6/42 | 56 | Â | Â | Case-series |
Arafah 1986 | mixed_p | microscopic_s | 120 | 0/120 | 27.9 | 96/120 | NA | NA | Â | Â | Case-series |
Archer 1982 | 17/0/0 | BRC | 17 | 0/17 | NA | 16/17 | NA | 24 | 24 | NA | Case-series |
Arijit 2005 | 0/15/14 | BRC | 29 | 29/0 | 31.9 | NA | NA | NA | NA | NA | Case-series |
Arimantas 2012 | 32/0/0 | microscopic_s | 32 | 0/32 | 31 | 19/32 | NA | 50.4 | Â | Â | Case-series |
Arturo 1979 | mixed_p | BRC | 14 | 0/14 | 29.71 | 10/14 | NA | NA | NA | NA | Case-series |
Asano 2001 | mixed_p | mixed_t | 13 | NA | 37.3 | NA | NA | NA | Â | Â | Non-RCT |
Ashu 2013 | 0/38/0 | CAB | 38 | 21/17 | 34.2 | 33/38 | NA | 16.1 | NA | NA | RCT |
Ashu 2012 | 0/38/0 | CAB | 38 | NA | NA | 30/38 | NA | 6 | NA | NA | RCT |
Barbara 2017 | mixed_p | BRC | 28 | 0/28 | 26 | 13/28 | NA | NA | NA | NA | Case-series |
Barbosa 2014 | mixed_p | mixed_DA | 21 | NA | NA | 17/21 | NA | NA | 6 | NA | Non-RCT |
Berezin 1995 | mixed_p | mixed_t | 75 | 75/0 | NA | 36/52 | NA | NA | NA | NA | Case-series |
Bevan 1987 | mixed_p | mixed_s | 67 | 19/48 | 32.4 | 34/67 | NA | NA | Â | Â | Case-series |
Bhansali 2010 | 0/15/0 | CAB | 15 | NA | 31.7 | 14/15 | NA | NA | NA | NA | Case-series |
Biswas 2005 | 89/0/0 | mixed_DA | 89 | NA | NA | NA | 57/89 | 37.2 | 37.2 | 21.6 | Non-RCT |
Cannavo 1999 | 26/11/0 | CAB | 37 | 5/32 | NA | 34/37 | NA | NA | 24 | NA | Case-series |
Carlo 1992 | mixed_p | CAB | 127 | 3/124 | NA | 114/127 | NA | NA | 14 | NA | Case-series |
Catarina 2018 | 0/67/0 | mixed_DA | 67 | 34/33 | 43 | 58/67 | NA | NA | NA | NA | Case-series |
Charpentier 1985 | mixed_p | mixed_s | 212 | NA | NA | 96/212 | 12/70 | 52.8 | Â | Â | Case-series |
Christine 2016 | 0/57/0 | mixed_DA | 57 | 30/27 | 37.5 | NA | NA | NA | NA | NA | Non-RCT |
Cintia 2011 | mixed_p | mixed_DA | 22 | NA | NA | 17/22 | NA | NA | 6 | NA | Non-RCT |
Coculescu 1983 | mixed_p | BRC | 22 | NA | NA | 19/22 | NA | NA | 10.1 | NA | Case-series |
Corsello 2003 | 0/0/10 | CAB | 10 | NA | NA | 5/10 | NA | NA | 38.9 | NA | Case-series |
Der-Yang 2002 | mixed_p | mixed_s | 44 | 1/43 | 46 | 32/44 | NA | NA | Â | Â | RCT |
Diane 2017 | 27/50/0 | mixed_s | 77 | NA | NA | 40/77 | 8/36 | 12 | Â | Â | Case-series |
Dogan 2015 | 42/0/0 | CAB | 42 | NA | NA | NA | 34/42 | 12 | NA | NA | Non-RCT |
Elise 1984 | 42/23/0 | mixed_s | 65 | NA | NA | 46/65 | 6/46 | 50 | Â | Â | Case-series |
Emir 2018 | mixed_p | mixed_DA | 25 | 18/7 | 39.96 | NA | NA | NA | NA | NA | Non-RCT |
Enrica 1989 | mixed_p | mixed_s | 22 | 1/21 | NA | NA | NA | NA | Â | Â | Case-series |
Erika1 2007 | mixed_p | mixed_DA | 31 | 0/31 | 33.0 | NA | NA | NA | NA | NA | Non-RCT |
Erika2 2007 | mixed_p | mixed_DA | 45 | 0/45 | 34.5 | NA | NA | NA | NA | NA | Non-RCT |
Esposito 2004 | mixed_p | mixed_s | 42 | 14/26 | 33.2 | 25/42 | 5/21 | 31 | Â | Â | Case-series |
Essais 2002 | 0/29/0 | BRC | 29 | 10/19 | NA | 27/29 | NA | NA | NA | NA | Case-series |
Etienne 1996 | mixed_p | mixed_DA | 10 | 2/8 | NA | 8/9 | NA | NA | NA | NA | Non-RCT |
Etienne 2009 | 0/122/0 | CAB | 122 | 50/72 | NA | 115/122 | NA | NA | NA | NA | Case-series |
Etual 2016 | 0/152/47 | mixed_DA | 199 | 114/85 | 40.9 | 145/199 | NA | NA | NA | NA | Non-RCT |
Eun-Hee 2009 | 0/10/0 | CAB | 10 | 10/0 | 37 | 6/10 | NA | NA | 19 | NA | Case-series |
Fadi 1996 | mixed_p | mixed_s | 64 | NA | NA | 59/64 | 25/59 | 147.6 | Â | Â | Case-series |
Ferrari 1997 | 0/85/0 | CAB | 85 | NA | NA | 52/85 | NA | NA | NA | NA | Case-series |
Frederick 2018 | mixed_p | endoscopic_s | 79 | 22/57 | 35.8 | 65/79 | NA | NA | Â | Â | Non-RCT |
Fritz 1985 | 13/11/0 | mixed_s | 24 | 0/24 | 29.7 | NA | 14/24 | NA | Â | Â | Case-series |
Giorgio 2006 | 28/38/0 | endoscopic_s | 66 | NA | NA | 50/66 | NA | NA | Â | Â | Case-series |
Giulio 1989 | mixed_p | mixed_s | 119 | 0/119 | NA | 73/119 | 5/40 | NA | Â | Â | Case-series |
Hae-Dong 2001 | mixed_p | endoscopic_s | 35 | NA | NA | 24/35 | NA | NA | Â | Â | Case-series |
Hae-Dong 1997 | mixed_p | endoscopic_s | 15 | 2/13 | 32.2 | 10/15 | NA | NA | Â | Â | Case-series |
Hamilton 2005 | mixed_p | mixed_s | 79 | NA | NA | 34/79 | NA | NA | Â | Â | Non-RCT |
Hancock 1980 | mixed_p | BRC | 36 | NA | NA | 28/36 | NA | NA | NA | NA | Case-series |
Helen 1999 | 32/0/0 | mixed_s | 32 | 0/32 | NA | 25/32 | 1/25 | 70 | Â | Â | Case-series |
Hidemitsu 2001 | mixed_p | microscopic_s | 13 | NA | NA | NA | NA | NA | Â | Â | Case-series |
Hidetoshi 2013 | mixed_p | mixed_s | 138 | NA | NA | 105/138 | 5/81 | 144 | Â | Â | Case-series |
Hildebrandt 1989 | 0/10/0 | BRC | 10 | NA | NA | 3/10 | NA | NA | 1 | NA | Case-series |
Hildebrandt 1992 | mixed_p | mixed_DA | 14 | NA | NA | 10/14 | NA | NA | NA | NA | Non-RCT |
Hofstetter 2011 | 32/53/0 | endoscopic_s | 85 | NA | NA | 51/85 | NA | NA | Â | Â | Case-series |
Huda 2010 | 40/0/0 | mixed_DA | 40 | 1/39 | NA | NA | 31/40 | 58 | 108 | 58 | Case-series |
Ilan 2007 | 0/0/10 | CAB | 10 | 10/0 | 38.2 | 9/10 | NA | NA | NA | NA | Case-series |
Ilan 2016 | 0/0/18 | mixed_DA | 18 | 16/2 | 36.3 | 11/18 | NA | NA | NA | NA | Case-series |
Ilan 2019 | mixed_p | mixed_DA | 28 | 28/0 | 71.3 | 24/27 | NA | NA | NA | NA | Case-series |
Ivan 2015 | 40/38/0 | mixed_t | 78 | 23/55 | 39.8 | 44/78 | NA | NA | 25 | NA | Non-RCT |
Jackson 2010 | 7/34/0 | endoscopic_s | 41 | NA | NA | 34/41 | 3/35 | NA | Â | Â | Case-series |
Jae 2009 | mixed_p | mixed_t | 117 | 31/86 | 35.1 | 103/117 | NA | NA | NA | NA | Case-series |
Johanna 1991 | 0/12/0 | BRC | 12 | 8/4 | 42.2 | NA | 11/12 | 12 | 58.8 | 4.3 | Case-series |
Johanna 1990 | 0/19/0 | BRC | 19 | 12/7 | NA | 16/19 | NA | 40.8 | 40.8 | NA | Case-series |
Jonathan 1992 | mixed_p | mixed_s | 82 | 7/75 | 30.5 | 65/82 | 5/65 | 51.7 | Â | Â | Case-series |
Katarina 2011 | mixed_p | mixed_DA | 14 | 6/8 | 39.7 | 14/14 | NA | NA | 6 | NA | Case-series |
Kharlip 2009 | mixed_p | CAB | 46 | NA | NA | NA | 25/46 | NA | NA | 3 | Case-series |
Kiyoshi 1984 | mixed_p | mixed_s | 12 | NA | NA | NA | NA | NA | Â | Â | Case-series |
Kreutzer 2008 | mixed_p | mixed_s | 212 | 133/79 | 36 | 102/212 | 17/91 | NA | Â | Â | Non-RCT |
Kristof 2002 | mixed_p | mixed_s | 37 | 16/21 | 31 | 10/37 | 2/10 | 44.4 | Â | Â | Case-series |
Kyung 2013 | mixed_p | BRC | 23 | 17/6 | 48 | 16/23 | NA | NA | 30 | NA | Case-series |
Liang 2018 | 0/0/42 | mixed_t | 42 | NA | NA | 21/42 | NA | NA | NA | NA | Non-RCT |
Lukas 2017 | mixed_p | mixed_t | 107 | 0/107 | 34 | 65/107 | NA | NA | NA | NA | Non-RCT |
Marco 2002 | mixed_p | mixed_s | 120 | 27/93 | 29.7 | 77/120 | 13/77 | 50.2 | Â | Â | Case-series |
Margarida 2017 | mixed_p | mixed_DA | 50 | 5/45 | 35.1 | NA | 14/50 | NA | 119.3 | NA | Non-RCT |
Maria 2015 | mixed_p | mixed_DA | 29 | NA | NA | 29/29 | NA | NA | NA | NA | Case-series |
MarÃa MartÃn 2013 | 47/0/0 | mixed_DA | 47 | NA | 30 | 39/47 | NA | NA | NA | NA | Case-series |
Mario 2017 | 24/0/0 | mixed_s | 24 | 5/19 | 34.8 | 8/24 | 1/8 | NA | Â | Â | Non-RCT |
Masami 2010 | mixed_p | CAB | 85 | NA | NA | 85/85 | NA | NA | NA | NA | Case-series |
Mia-Maiken 2013 | mixed_p | mixed_DA | 12 | 5/7 | 39.7 | 8/12 | NA | NA | NA | NA | Case-series |
Michael 2009 | mixed_p | mixed_s | 176 | 20/156 | 31 | NA | NA | NA | Â | Â | Non-RCT |
Miguel 1982 | mixed_p | microscopic_s | 100 | NA | NA | 68/100 | 5/68 | NA | Â | Â | Case-series |
Moon 2011 | mixed_p | BRC | 36 | 25/11 | NA | 29/36 | NA | NA | NA | NA | Case-series |
Muratori 1997 | 26/0/0 | CAB | 26 | 0/26 | NA | 25/26 | 13/19 | 12 | 12 | NA | Case-series |
Muriel 2011 | 24/10/0 | microscopic_s | 34 | 4/30 | NA | 32/34 | 2/32 | 33.5 | Â | Â | Case-series |
Mussa 2015 | 0/0/16 | CAB | 16 | 10/6 | 34.9 | 6/16 | NA | NA | NA | NA | Case-series |
Myoung 2017 | 30/59/0 | mixed_DA | 89 | 27/62 | 33.7 | NA | 51/89 | 25.8 | 28.9 | NA | Case-series |
Na 2018 | 31/32/0 | mixed_s | 63 | NA | 57 | 48/63 | 3/48 | 53 | Â | Â | Case-series |
Naguib 1986 | mixed_p | mixed_t | 190 | 0/190 | 28.6 | NA | NA | NA | 28.8 | NA | Non-RCT |
Nazir 2015 | mixed_p | CAB | 19 | 1/18 | 27.3 | 18/19 | NA | NA | NA | NA | Non-RCT |
Niki 2013 | 0/12/0 | CAB | 12 | 11/1 | 40.5 | 11/12 | NA | NA | NA | NA | Case-series |
Nissim 1982 | 0/7/0 | BRC | 7 | NA | NA | 4/7 | NA | NA | NA | NA | Case-series |
Oksana 2018 | 0/0/68 | mixed_t | 68 | 60/8 | 41.5 | 35/68 | NA | NA | 104.7 | NA | Case-series |
Oluwaseun 2019 | mixed_p | mixed_DA | 69 | NA | NA | 29/69 | NA | 6 | NA | NA | Case-series |
Omar 1983 | 28/16/0 | mixed_s | 44 | 0/44 | 26.8 | 29/44 | 16/29 | 41.5 | Â | Â | Case-series |
Paepegaey 2017 | 0/260/0 | CAB | 260 | 135/125 | 36.2 | 157/260 | 14/35 | NA | NA | NA | Case-series |
Paluzzi 2013 | 11/42/0 | endoscopic_s | 53 | NA | NA | 42/53 | NA | NA | Â | Â | Case-series |
Panagiotis 2011 | mixed_p | mixed_DA | 79 | 17/62 | 35.3 | NA | 11/26 | 49 | 79 | NA | Case-series |
Paul 1983 | mixed_p | mixed_s | 40 | 0/40 | NA | 25/40 | 9/25 | 23 | Â | Â | Case-series |
Pelkonen 1981 | mixed_p | mixed_s | 60 | 15/45 | NA | NA | NA | NA | Â | Â | Case-series |
Pietro 2005 | mixed_p | mixed_s | 151 | NA | NA | 93/151 | NA | NA | Â | Â | Case-series |
Raverot 2010 | mixed_p | mixed_s | 94 | 32/62 | 37.8 | 60/94 | 19/60 | 138 | Â | Â | Case-series |
Renata 2013 | mixed_p | CAB | 61 | 13/48 | 34.4 | 57/61 | NA | 60 | 60 | NA | Case-series |
Renata 2015 | mixed_p | CAB | 32 | 32/0 | 42 | 31/32 | NA | 24 | 24 | NA | Non-RCT |
Ronald 1982 | 22/14/0 | mixed_s | 36 | NA | NA | NA | 1/35 | NA | Â | Â | Case-series |
Rudolf 1985 | 27/0/0 | microscopic_s | 27 | NA | NA | 19/27 | NA | NA | Â | Â | Case-series |
Safak 2016 | 0/113/0 | endoscopic_s | 113 | NA | NA | 51/113 | NA | 36 | Â | Â | Case-series |
Safak 2016 | 19/0/10 | endoscopic_s | 29 | NA | NA | 15/29 | NA | 36 | Â | Â | Â |
Sandhya 2018 | mixed_p | mixed_DA | 28 | 0/28 | NA | 16/18 | 5/16 | 12 | 216 | 36 | Case-series |
Sandhya 2017 | mixed_p | mixed_DA | 16 | 0/16 | NA | 15/16 | NA | NA | NA | NA | Case-series |
Schlechte 1985 | mixed_p | microscopic_s | 68 | 0/68 | NA | 37/68 | 12/37 | 60.00 | Â | Â | Case-series |
Sema 2016 | mixed_p | mixed_DA | 67 | 17/50 | NA | NA | 31/67 | 108.8 | 76.9 | 16.1 | Non-RCT |
Sema 2018 | mixed_p | mixed_DA | 308 | NA | 71 | NA | NA | NA | NA | NA | Non-RCT |
Shigetoshi 2009 | 17/12/0 | endoscopic_s | 29 | NA | NA | 21/29 | NA | NA | Â | Â | Case-series |
Shrikrishna 2009 | mixed_p | mixed_DA | 39 | 9/30 | NA | 14/39 | NA | NA | NA | NA | Case-series |
Shrikrishna 2010 | 0/0/10 | CAB | 10 | 5/5 | 36.1 | 8/10 | NA | NA | NA | NA | Case-series |
Steven 1996 | 11/23/0 | mixed_s | 34 | 8/26 | 23.3 | 9/34 | NA | NA | Â | Â | Case-series |
Taizo 1991 | mixed_p | mixed_s | 35 | 0/35 | NA | 22/35 | NA | NA | Â | Â | Case-series |
Takakazu 2002 | mixed_p | mixed_s | 32 | 12/20 | 32 | 14/32 | NA | NA | Â | Â | Case-series |
Tevfik 2001 | mixed_p | mixed_DA | 34 | 4/30 | 33.1 | 24/34 | NA | NA | NA | NA | RCT |
Thomas 2011 | 45/15/0 | mixed_DA | 60 | NA | NA | NA | 43/60 | 65 | 59 | 6 | Case-series |
Thomson 1985 | mixed_p | microscopic_s | 77 | NA | NA | 53/77 | NA | NA | Â | Â | Case-series |
Timothy 2015 | mixed_p | endoscopic_s | 66 | 22/44 | 36.7 | 45/66 | NA | 12 | Â | Â | Case-series |
Vanessa 2012 | mixed_p | mixed_s | 63 | 18/45 | 31 | 29/63 | 10/29 | 36 | Â | Â | Case-series |
Verena 2017 | mixed_p | CAB | 53 | 31/22 | 40 | NA | NA | NA | 9 | NA | Case-series |
Wang 1987 | mixed_p | BRC | 24 | NA | NA | NA | 19/24 | 40.8 | 58.8 | NA | Case-series |
Wang 2015 | 132/176/0 | endoscopic_s | 308 | NA | NA | 261/308 | NA | NA | Â | Â | Case-series |
Winnie 2018 | mixed_p | mixed_s | 31 | 31/0 | 40.8 | NA | NA | 41.9 | Â | Â | Case-series |
Wolfsberger 2003 | 0/11/0 | mixed_s | 11 | 11/0 | 41 | 8/11 | NA | 84 | Â | Â | Case-series |
Xin 2011 | mixed_p | mixed_s | 87 | 87/0 | 38 | 46/87 | 9/45 | 45 | Â | Â | Case-series |
Yan 2015 | mixed_p | mixed_s | 99 | NA | NA | 71/99 | NA | NA | Â | Â | Case-series |
Yang 2015 | mixed_p | mixed_s | 9 | 5/4 | NA | NA | NA | NA | Â | Â | Case-series |
Yan-Long 2018 | mixed_p | endoscopic_s | 52 | 14/38 | 37.69 | 40/52 | 6/40 | 13.5 | Â | Â | Case-series |
Yi 2018 | mixed_p | mixed_s | 36 | 11/25 | NA | 34/36 | NA | NA | Â | Â | Case-series |
Yi-Jun 2017 | mixed_p | microscopic_s | 184 | 184/0 | 36.3 | 57/187 | NA | NA | Â | Â | Case-series |
Youichi 1986 | mixed_p | microscopic_s | 98 | 16/82 | 31 | 45/98 | NA | NA | Â | Â | Case-series |
Youngki 2014 | 0/44/0 | mixed_DA | 44 | 28/16 | 36.8 | 34/44 | NA | NA | NA | NA | Case-series |