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Table 1 Basic characteristics of the included studies

From: Are dopamine agonists still the first-choice treatment for prolactinoma in the era of endoscopy? A systematic review and meta-analysis

Study name I/A/Ga Interventionb No. Male/female Meanage/y Biochemical cure ratec Recurrent rated Duration 1 Duration 2 Duration 3 Study type
Adam 2013 mixed_p endoscopic_s 17 NA NA 8/17 NA 40    Case-series
Akira 2006 mixed_p mixed_s 13 3/10 NA NA NA NA    Case-series
Albert 1992 0/29/0 BRC 29 14/15 NA NA NA NA NA NA Non-RCT
Alessandro 2013 mixed_p CAB 43 8/35 33.65 24/43 NA NA 12 NA Case-series
Alexander 2018 60/0/0 endoscopic_s 60 10/50 33.5 40/60 NA 37    Non-RCT
Amir 2007 12/13/0 endoscopic_s 25 NA NA 21/25 NA 19    Case-series
Amit 2015 0/71/0 CAB 71 71/0 44.7 51/71 NA 80.3 NA NA Case-series
Andreja 2012 39/22/0 endoscopic_s 61 NA NA 54/61 NA NA    Case-series
Annamaria1 2004 mixed_p CAB 20 20/0 34 20/20 NA NA NA NA Non-RCT
Annamaria2 2004 10/41/0 CAB 51 51/0 32.9 39/51 NA 24    Non-RCT
Annamaria 2007 115/79/0 CAB 194 NA NA NA 81/194 68.6 42.6 45.8 Case-series
Annamaria 1997 8/19/0 mixed_DA 27 NA NA 23/27 NA NA NA NA Case-series
Annamaria 2000 0/45/0 mixed_DA 45 17/45 NA 40/45 NA NA NA NA Non-RCT
Antonell 2001 44/28/0 mixed_DA 188 NA NA 138/188 NA 8.3 NA NA Non-RCT
Antonio 2007 mixed_p mixed_s 65 20/45 36 42/65 6/42 56    Case-series
Arafah 1986 mixed_p microscopic_s 120 0/120 27.9 96/120 NA NA    Case-series
Archer 1982 17/0/0 BRC 17 0/17 NA 16/17 NA 24 24 NA Case-series
Arijit 2005 0/15/14 BRC 29 29/0 31.9 NA NA NA NA NA Case-series
Arimantas 2012 32/0/0 microscopic_s 32 0/32 31 19/32 NA 50.4    Case-series
Arturo 1979 mixed_p BRC 14 0/14 29.71 10/14 NA NA NA NA Case-series
Asano 2001 mixed_p mixed_t 13 NA 37.3 NA NA NA    Non-RCT
Ashu 2013 0/38/0 CAB 38 21/17 34.2 33/38 NA 16.1 NA NA RCT
Ashu 2012 0/38/0 CAB 38 NA NA 30/38 NA 6 NA NA RCT
Barbara 2017 mixed_p BRC 28 0/28 26 13/28 NA NA NA NA Case-series
Barbosa 2014 mixed_p mixed_DA 21 NA NA 17/21 NA NA 6 NA Non-RCT
Berezin 1995 mixed_p mixed_t 75 75/0 NA 36/52 NA NA NA NA Case-series
Bevan 1987 mixed_p mixed_s 67 19/48 32.4 34/67 NA NA    Case-series
Bhansali 2010 0/15/0 CAB 15 NA 31.7 14/15 NA NA NA NA Case-series
Biswas 2005 89/0/0 mixed_DA 89 NA NA NA 57/89 37.2 37.2 21.6 Non-RCT
Cannavo 1999 26/11/0 CAB 37 5/32 NA 34/37 NA NA 24 NA Case-series
Carlo 1992 mixed_p CAB 127 3/124 NA 114/127 NA NA 14 NA Case-series
Catarina 2018 0/67/0 mixed_DA 67 34/33 43 58/67 NA NA NA NA Case-series
Charpentier 1985 mixed_p mixed_s 212 NA NA 96/212 12/70 52.8    Case-series
Christine 2016 0/57/0 mixed_DA 57 30/27 37.5 NA NA NA NA NA Non-RCT
Cintia 2011 mixed_p mixed_DA 22 NA NA 17/22 NA NA 6 NA Non-RCT
Coculescu 1983 mixed_p BRC 22 NA NA 19/22 NA NA 10.1 NA Case-series
Corsello 2003 0/0/10 CAB 10 NA NA 5/10 NA NA 38.9 NA Case-series
Der-Yang 2002 mixed_p mixed_s 44 1/43 46 32/44 NA NA    RCT
Diane 2017 27/50/0 mixed_s 77 NA NA 40/77 8/36 12    Case-series
Dogan 2015 42/0/0 CAB 42 NA NA NA 34/42 12 NA NA Non-RCT
Elise 1984 42/23/0 mixed_s 65 NA NA 46/65 6/46 50    Case-series
Emir 2018 mixed_p mixed_DA 25 18/7 39.96 NA NA NA NA NA Non-RCT
Enrica 1989 mixed_p mixed_s 22 1/21 NA NA NA NA    Case-series
Erika1 2007 mixed_p mixed_DA 31 0/31 33.0 NA NA NA NA NA Non-RCT
Erika2 2007 mixed_p mixed_DA 45 0/45 34.5 NA NA NA NA NA Non-RCT
Esposito 2004 mixed_p mixed_s 42 14/26 33.2 25/42 5/21 31    Case-series
Essais 2002 0/29/0 BRC 29 10/19 NA 27/29 NA NA NA NA Case-series
Etienne 1996 mixed_p mixed_DA 10 2/8 NA 8/9 NA NA NA NA Non-RCT
Etienne 2009 0/122/0 CAB 122 50/72 NA 115/122 NA NA NA NA Case-series
Etual 2016 0/152/47 mixed_DA 199 114/85 40.9 145/199 NA NA NA NA Non-RCT
Eun-Hee 2009 0/10/0 CAB 10 10/0 37 6/10 NA NA 19 NA Case-series
Fadi 1996 mixed_p mixed_s 64 NA NA 59/64 25/59 147.6    Case-series
Ferrari 1997 0/85/0 CAB 85 NA NA 52/85 NA NA NA NA Case-series
Frederick 2018 mixed_p endoscopic_s 79 22/57 35.8 65/79 NA NA    Non-RCT
Fritz 1985 13/11/0 mixed_s 24 0/24 29.7 NA 14/24 NA    Case-series
Giorgio 2006 28/38/0 endoscopic_s 66 NA NA 50/66 NA NA    Case-series
Giulio 1989 mixed_p mixed_s 119 0/119 NA 73/119 5/40 NA    Case-series
Hae-Dong 2001 mixed_p endoscopic_s 35 NA NA 24/35 NA NA    Case-series
Hae-Dong 1997 mixed_p endoscopic_s 15 2/13 32.2 10/15 NA NA    Case-series
Hamilton 2005 mixed_p mixed_s 79 NA NA 34/79 NA NA    Non-RCT
Hancock 1980 mixed_p BRC 36 NA NA 28/36 NA NA NA NA Case-series
Helen 1999 32/0/0 mixed_s 32 0/32 NA 25/32 1/25 70    Case-series
Hidemitsu 2001 mixed_p microscopic_s 13 NA NA NA NA NA    Case-series
Hidetoshi 2013 mixed_p mixed_s 138 NA NA 105/138 5/81 144    Case-series
Hildebrandt 1989 0/10/0 BRC 10 NA NA 3/10 NA NA 1 NA Case-series
Hildebrandt 1992 mixed_p mixed_DA 14 NA NA 10/14 NA NA NA NA Non-RCT
Hofstetter 2011 32/53/0 endoscopic_s 85 NA NA 51/85 NA NA    Case-series
Huda 2010 40/0/0 mixed_DA 40 1/39 NA NA 31/40 58 108 58 Case-series
Ilan 2007 0/0/10 CAB 10 10/0 38.2 9/10 NA NA NA NA Case-series
Ilan 2016 0/0/18 mixed_DA 18 16/2 36.3 11/18 NA NA NA NA Case-series
Ilan 2019 mixed_p mixed_DA 28 28/0 71.3 24/27 NA NA NA NA Case-series
Ivan 2015 40/38/0 mixed_t 78 23/55 39.8 44/78 NA NA 25 NA Non-RCT
Jackson 2010 7/34/0 endoscopic_s 41 NA NA 34/41 3/35 NA    Case-series
Jae 2009 mixed_p mixed_t 117 31/86 35.1 103/117 NA NA NA NA Case-series
Johanna 1991 0/12/0 BRC 12 8/4 42.2 NA 11/12 12 58.8 4.3 Case-series
Johanna 1990 0/19/0 BRC 19 12/7 NA 16/19 NA 40.8 40.8 NA Case-series
Jonathan 1992 mixed_p mixed_s 82 7/75 30.5 65/82 5/65 51.7    Case-series
Katarina 2011 mixed_p mixed_DA 14 6/8 39.7 14/14 NA NA 6 NA Case-series
Kharlip 2009 mixed_p CAB 46 NA NA NA 25/46 NA NA 3 Case-series
Kiyoshi 1984 mixed_p mixed_s 12 NA NA NA NA NA    Case-series
Kreutzer 2008 mixed_p mixed_s 212 133/79 36 102/212 17/91 NA    Non-RCT
Kristof 2002 mixed_p mixed_s 37 16/21 31 10/37 2/10 44.4    Case-series
Kyung 2013 mixed_p BRC 23 17/6 48 16/23 NA NA 30 NA Case-series
Liang 2018 0/0/42 mixed_t 42 NA NA 21/42 NA NA NA NA Non-RCT
Lukas 2017 mixed_p mixed_t 107 0/107 34 65/107 NA NA NA NA Non-RCT
Marco 2002 mixed_p mixed_s 120 27/93 29.7 77/120 13/77 50.2    Case-series
Margarida 2017 mixed_p mixed_DA 50 5/45 35.1 NA 14/50 NA 119.3 NA Non-RCT
Maria 2015 mixed_p mixed_DA 29 NA NA 29/29 NA NA NA NA Case-series
María Martín 2013 47/0/0 mixed_DA 47 NA 30 39/47 NA NA NA NA Case-series
Mario 2017 24/0/0 mixed_s 24 5/19 34.8 8/24 1/8 NA    Non-RCT
Masami 2010 mixed_p CAB 85 NA NA 85/85 NA NA NA NA Case-series
Mia-Maiken 2013 mixed_p mixed_DA 12 5/7 39.7 8/12 NA NA NA NA Case-series
Michael 2009 mixed_p mixed_s 176 20/156 31 NA NA NA    Non-RCT
Miguel 1982 mixed_p microscopic_s 100 NA NA 68/100 5/68 NA    Case-series
Moon 2011 mixed_p BRC 36 25/11 NA 29/36 NA NA NA NA Case-series
Muratori 1997 26/0/0 CAB 26 0/26 NA 25/26 13/19 12 12 NA Case-series
Muriel 2011 24/10/0 microscopic_s 34 4/30 NA 32/34 2/32 33.5    Case-series
Mussa 2015 0/0/16 CAB 16 10/6 34.9 6/16 NA NA NA NA Case-series
Myoung 2017 30/59/0 mixed_DA 89 27/62 33.7 NA 51/89 25.8 28.9 NA Case-series
Na 2018 31/32/0 mixed_s 63 NA 57 48/63 3/48 53    Case-series
Naguib 1986 mixed_p mixed_t 190 0/190 28.6 NA NA NA 28.8 NA Non-RCT
Nazir 2015 mixed_p CAB 19 1/18 27.3 18/19 NA NA NA NA Non-RCT
Niki 2013 0/12/0 CAB 12 11/1 40.5 11/12 NA NA NA NA Case-series
Nissim 1982 0/7/0 BRC 7 NA NA 4/7 NA NA NA NA Case-series
Oksana 2018 0/0/68 mixed_t 68 60/8 41.5 35/68 NA NA 104.7 NA Case-series
Oluwaseun 2019 mixed_p mixed_DA 69 NA NA 29/69 NA 6 NA NA Case-series
Omar 1983 28/16/0 mixed_s 44 0/44 26.8 29/44 16/29 41.5    Case-series
Paepegaey 2017 0/260/0 CAB 260 135/125 36.2 157/260 14/35 NA NA NA Case-series
Paluzzi 2013 11/42/0 endoscopic_s 53 NA NA 42/53 NA NA    Case-series
Panagiotis 2011 mixed_p mixed_DA 79 17/62 35.3 NA 11/26 49 79 NA Case-series
Paul 1983 mixed_p mixed_s 40 0/40 NA 25/40 9/25 23    Case-series
Pelkonen 1981 mixed_p mixed_s 60 15/45 NA NA NA NA    Case-series
Pietro 2005 mixed_p mixed_s 151 NA NA 93/151 NA NA    Case-series
Raverot 2010 mixed_p mixed_s 94 32/62 37.8 60/94 19/60 138    Case-series
Renata 2013 mixed_p CAB 61 13/48 34.4 57/61 NA 60 60 NA Case-series
Renata 2015 mixed_p CAB 32 32/0 42 31/32 NA 24 24 NA Non-RCT
Ronald 1982 22/14/0 mixed_s 36 NA NA NA 1/35 NA    Case-series
Rudolf 1985 27/0/0 microscopic_s 27 NA NA 19/27 NA NA    Case-series
Safak 2016 0/113/0 endoscopic_s 113 NA NA 51/113 NA 36    Case-series
Safak 2016 19/0/10 endoscopic_s 29 NA NA 15/29 NA 36    
Sandhya 2018 mixed_p mixed_DA 28 0/28 NA 16/18 5/16 12 216 36 Case-series
Sandhya 2017 mixed_p mixed_DA 16 0/16 NA 15/16 NA NA NA NA Case-series
Schlechte 1985 mixed_p microscopic_s 68 0/68 NA 37/68 12/37 60.00    Case-series
Sema 2016 mixed_p mixed_DA 67 17/50 NA NA 31/67 108.8 76.9 16.1 Non-RCT
Sema 2018 mixed_p mixed_DA 308 NA 71 NA NA NA NA NA Non-RCT
Shigetoshi 2009 17/12/0 endoscopic_s 29 NA NA 21/29 NA NA    Case-series
Shrikrishna 2009 mixed_p mixed_DA 39 9/30 NA 14/39 NA NA NA NA Case-series
Shrikrishna 2010 0/0/10 CAB 10 5/5 36.1 8/10 NA NA NA NA Case-series
Steven 1996 11/23/0 mixed_s 34 8/26 23.3 9/34 NA NA    Case-series
Taizo 1991 mixed_p mixed_s 35 0/35 NA 22/35 NA NA    Case-series
Takakazu 2002 mixed_p mixed_s 32 12/20 32 14/32 NA NA    Case-series
Tevfik 2001 mixed_p mixed_DA 34 4/30 33.1 24/34 NA NA NA NA RCT
Thomas 2011 45/15/0 mixed_DA 60 NA NA NA 43/60 65 59 6 Case-series
Thomson 1985 mixed_p microscopic_s 77 NA NA 53/77 NA NA    Case-series
Timothy 2015 mixed_p endoscopic_s 66 22/44 36.7 45/66 NA 12    Case-series
Vanessa 2012 mixed_p mixed_s 63 18/45 31 29/63 10/29 36    Case-series
Verena 2017 mixed_p CAB 53 31/22 40 NA NA NA 9 NA Case-series
Wang 1987 mixed_p BRC 24 NA NA NA 19/24 40.8 58.8 NA Case-series
Wang 2015 132/176/0 endoscopic_s 308 NA NA 261/308 NA NA    Case-series
Winnie 2018 mixed_p mixed_s 31 31/0 40.8 NA NA 41.9    Case-series
Wolfsberger 2003 0/11/0 mixed_s 11 11/0 41 8/11 NA 84    Case-series
Xin 2011 mixed_p mixed_s 87 87/0 38 46/87 9/45 45    Case-series
Yan 2015 mixed_p mixed_s 99 NA NA 71/99 NA NA    Case-series
Yang 2015 mixed_p mixed_s 9 5/4 NA NA NA NA    Case-series
Yan-Long 2018 mixed_p endoscopic_s 52 14/38 37.69 40/52 6/40 13.5    Case-series
Yi 2018 mixed_p mixed_s 36 11/25 NA 34/36 NA NA    Case-series
Yi-Jun 2017 mixed_p microscopic_s 184 184/0 36.3 57/187 NA NA    Case-series
Youichi 1986 mixed_p microscopic_s 98 16/82 31 45/98 NA NA    Case-series
Youngki 2014 0/44/0 mixed_DA 44 28/16 36.8 34/44 NA NA NA NA Case-series
  1. aI/A/G: numbers of patients with microprolactinoma/macroprolactinoma/giant prolactinoma; mixed_p: mixed_prolactinoma, data of this part is inseparable, which includes patients with macroprolactinoma, microprolactinoma, and giant prolactinoma; bmixed_t: mixed treatment,treatments within this study include DAs and surgery and data of each treatment is available; mixed_s: mixed_surgery, data include patients with microscopic surgery and endoscopic surgery; microscopic_s: microscopic_surgery; endoscopic_s: endoscopic_surgery; DAs: dopamine agonists; BRC: bromocriptine; CAB: cabergoline; c cured/treated; d replased/cured; e mean follow up duration months; NA not applicable, because the data was not provided by included studies. Duration 1: follow up duration (month); Duration 2: DAs treatment duration (month), only for studies with DAs; Duration 3: follow-up duration after DAs withdrawal (month), only for studies with DAs; No.: sample size of included study