Table 3 Subgroup analysis of the recurrence rate in patients treated with DAs and surgery treatment

Total

0.57 (0.48, 0.67)

19

835

0.19 (0.15, 0.24)

36

1215

Microprolactinoma

0.63 (0.49, 0.78)

7

380

0.10 (0.04, 0.17)

10

206

Macroprolactinoma

0.60 (0.39, 0.81)

6

226

0.34 (0.11, 0.56)

8

112

Giant prolactinoma

NA^a

NA^a

NA^a

NA^a

NA^a

NA^a

1980–1989

0.79

1

24

0.28 (0.16, 0.39)

13

374

1990–1999

0.81 (0.58, 1.04)

2

31

0.17 (− 0.01, 0.35)

3

149

2000–2009

0.51 (0.37, 0.65)

4

329

0.15 (0.09, 0.21)

6

278

2010–2019

0.54 (0.41, 0.67)

12

451

0.15 (0.09, 0.20)

14

414

Bromocriptine

0.86 (0.73, 0.98)

2

36

NA^b

NA^b

NA^b

Cabergoline

0.55 (0.39, 0.70)

6

336

NA^b

NA^b

NA^b

Microscopic surgery

NA^b

NA^b

NA^b

0.13 (0.05, 0.21)

5

177

Endoscopic surgery

NA^b

NA^b

NA^b

0.13 (0.05, 0.21)

3

75