Table 3 Results of lung nodule biopsy and immunohistochemistry analysis

25 Jan. 2019

(Lung mass and soft tissue). Malignant tumors can be seen in the puncture tissues submitted for examination. Most of the tumor cells are fusiform, and some are epithelioid. Considering the history of the disease, the possibility of metastatic tumors is high. Pulmonary sarcomatoid carcinoma is not excluded. Supplementary diagnosis: (lung tumor soft tissue 1) (lung tumor soft tissue 2) malignant tumors can be seen in the submitted puncture tissue. Most of the tumor cells are fusiform, and some are epithelioid. Combined with the results of immunohistochemistry, they tend to be carcinosarcoma

CK mixed (individually weak +), P40 ( −) TTF-1 (minority +), Ki-67 (40% +), Vimentin ( +), CK7 (minority +), Napsin A ( −), GFAP ( −), ATRX( +), P53 (mutant), S-100 ( −) WT-1 ( −). Oligo-2 ( −)

Note: This patient has a history of intracranial glioma, but there is no typical component of glioma in the lung tumor puncture tissue. Since the extracranial metastasis of glioma is very rare, it is recommended that both sites are primary tumors. Further detection of P53 germline mutations to exclude the possibility of Li-Fraumeni syndrome