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Table 2 Largest past case series of meningiomas in children and adolescents

From: Trans-eyebrow supraorbital endoscope-assisted keyhole approach to suprasellar meningioma in pediatric patient: case report and literature review

Case series Study period n Age Sex (M:F) Tumor location (supratentorial only) NF1 NF2 Histologic grade (%) GTR, % Relapse Mortality
Perilongo et al. 1992 [13] 1975–1991 20 1,5–17 15:5 Convexital–40% (8)
Sphenoid wing–10% (2)
Parasagittal–10% (2)
1 2 Malignant–45% (9)
Benign–55% (11)
60% 8 1
Germano et al. 1994 [14] 1948–1990 23 6–21 14:9 Supratentorial–70% (16)
Intraventricular–13% (3)
0 0 Grade I–71% (15)
Grade II–29% (6)
Grade III–0
Non-specified–9.5% (2)
60% 0 0
Erdinçeret al. 1998 [15] 1968–1994 29 0–15 18:11 Convexital–58.6% (17)
Intraventricular–10.3% (3)
Intraosseous–3.4% (1)
Sphenoid wing–6.9% (2)
Parasellar–6.9% (2)
7 5 Grade I–93% (27)
Grade II–3.4% (1)
Grade III–3.4% (1)
86.2% 3 7
Amirjanshidi et al. 2000 [16] 1983–1998 24 4–17 11:13 Convexital–33.3% (8)
Parasagittal–12.5% (3)
Parasellar–12.5% (3)
Suprasellar–4.2% (1)
0 0 Grade I–95.8% (23)
Grade II–0
Grade III–4.2% (1)
75% 6 1
Lund–Johansen et al. 2001 [17] 1972–1998 27 0,3–20 16:11 Convexital–33.3% (9)
Parasagittal–14.8% (4)
Clinoid process–11.1% (3)
Sphenoid wing–7.4% (2)
0 3 Grade I–96.3% (26)
Grade II–3.7% (1)
Grade III–0
92.6% 8 3
Perry et al. 2001 [18] 1972–2000 33 3–18 19:14 Convexital and parasagittal–49% (26)
Skull base–6% (3)
Anterior visual pathway and orbit–8% (4)
1 14 Grade I–40% (21)
Grade II–49% (26)
Grade III–11% (6)
8 5
Rochat et al. 2004 [19] 1935–1984 22 0–14 8:14 Supratentorial:
-Midline–18.2% (4)
-Lateral–68.2% (15)
0 3 Grade I–91% (20)
Grade II–9% (2)
Grade III–0
68% 9 13
Rushing et al. 2005 [20] 1970–2004 87 0.4–20 52:35 Supratentorial–64% (55)
Intraventricular–12% (10)
0 9 Grade I–70.1% (61)
Grade II–22.9% (20)
Grade III–4.6% (4)
58.6% 15 9
Arivazhagan et al. 2008 [12] 1990–2005 33 5–18 19:14 Convexital–15.2 (5)
Intraventricular–24.2% (8)
Parasagittal–3% (1)
Sphenoidal–6.1% (2)
Parasellar/suprasellar–9.1% (3)
3 0 Grade I–75.6% (25)
Grade II–9% (3)
Grade III–15% (5)
66.7% 6 3
Menon et al. 2009 [21] 1982–2005 38 2.5–20 20:18 Parasagittal–24.4% (10)
Skull base–24.4% (10)
Convexital–12.2% (5)
Intraventricular–7.3% (3)
8 3 Grade I–73.13% (30)
Grade II–24.4% (9)
Grade III–4.8% (2)
76.3% 7 1
Gao et al. 2009 [11] 1993–2008 54 2.8–18 29:25 Convexital–14.8% (8)
Parasagittal–14.8% (8)
Sphenoidal ridge–5.6% (3)
Suprasellar–1.9% (1)
0 5 Grade I–81.5% (44)
Grade II–11.1% (6)
Grade III–7.4% (4)
72.2% 10 9
Li and Zhao, 2009 [22] 2000–2007 34 2–17 16:18 Convexital–79.4% (27)
Parasagittal–5.8% (2)
Tuberculum sellae–2.9% (1)
Sphenoid ringe–2.9% (1)
Cavernous sinus–2.9% (1)
0 0 Grade I–79.4% (27)
Grade II–8.8% (3)
Grade III–11.76% (4)
58.8% 7 6
Lakhdar et al. 2010 [23] 1998–2007 21 2–16 13:8 Convexital–47.6% (10)
Parasagittal–23.8% (5)
Sphenoidal–9.5% (2)
Suprasellar–9.5% (2)
Intraventricular–9.5% (2)
1 1 Grade I–61.9% (13)
Grade II–9.5% (2)
Grade III–28.7% (6)
61.9% 7 2
Thuijs et al. 2012 [24] 1974–2010 72 0–18 39:33 Supratentorial–52.7% (38)
-Convexital–37.5% (27)
Infratentorial–18.1% (13)
10 3 Grade I–73.6% (53)
Grade II–18.1% (13)
Grade III–8.3% (6)
48.6% 19 7
Ravindranath et al. 2013 [25] 1988–2012 31 0.6–18 22:9 Convexital–42% (13)
Skull base–49% (15)
Multiple–6.4% (2)
Intraventricular–3% (1)
2 2 Grade I–64% (20)
Grade II–26% (8)
Grade III–9% (3)
83% 20 1
Li et al. 2016 [26] 2005-–2014 44 3–18 20:24 Anterior fossa–16.2%
Middle fossa–32.4%:
-Sphenoid wing–10.8%
-Parasellar8.1%
-Cavernous sinus–2.7%
-Other–10.8%
1 3 Grade I–63.7% (28)
Grade II–27.3% (12)
Grade III–9% (4)
52.3% 10 4
Grossbach et al. 2017 [27] 1948–2015 39 0–20 15:24 Convexital–58.8% (20)
Skull base–55.8% (19)
4 4 Grade I–69% (27)
Grade II–26% (10)
Grade III–5% (2)
- 15 2
Ilkay et al. 2020 [28] 1994–2001 23 8–18 12:11 Superficial (convexital and parasagittal)–48.2%
Skull base (25.9%):
-Foramen magnum 8.7%
-Retro-orbital 13%
-Anterior cranial fossa 8.7%
-Suprasellar/parasellar 0%
Deep (pineal, lateral ventricles, ambient cistern)–11.1%
1 5 Grade I–55.5% (15)
Grade II–33.3% (9)
Grade III–11.1% (3)
70.4% 10 3
He et al. 2020 [29] 2009–2019 39 1–18 22:17 Convexital–35.6% (14)
Skull base–30.7% (12)
-Sellar region–2.5% (1)
Intraventricular–17.9% (7)
2 1 Grade I–66.7% (26)
Grade II–25.6% (10)
Grade III–7.7% (3)
71.8% 13 2
  1. Case series of pediatric meningiomas (20 and more cases). It takes a long time to obtain data of 20–87 cases because of rarity of meningiomas in children and adolescents. Suprasellar and parasellar meningioma locations are rather rare (in bold) compared to convexital and parasagittal location. It is notable that recurrence rate correlates with presence of neurofibromatosis as well as with the malignancy rate and with the amount of GTR. It is remarkable that most authors do not classify “parasellar” or “suprasellar” meningiomas by the location of dural attachment (clinoid process, tuberculum sellae, etc.). However, this tumor feature can affect the preferred surgical strategy