Fig. 6

Over-expression of TR1 increases the expression of Na⁺-K⁺-ATP in PD mouse and cell models. A KEGG pathway analysis of the expression of Na⁺-K⁺-ATP in the Tg-A53T and WT groups. B Enlargement in A. C KEGG pathway analysis of the expression of Na⁺-K⁺-ATP in the Tg-A53T and TR1-A53T groups. D The part of enlargement in C. E The expression of Na⁺-K⁺-ATP in control, MPP⁺, MPP⁺-LV, and MPP⁺-TR1 groups by immunofluorescence. F Relative average fluorescence intensity of Na⁺-K⁺-ATP. *p < 0.05, MPP⁺vs. control group, **p < 0.05, MPP⁺vs. MPP⁺-TR1 group. WT (normal C57BL/6 mice). Control (N2a cells cultivated with DMEM); MPP⁺(N2a cells used MPP⁺(1 mM) for 48 h), MPP⁺-LV (N2a cells overexpressing lentivirus for 24 h then used MPP⁺ (1 mM) for 48 h. MPP⁺-TR1(N2a cells overexpressing lentivirus-TR1 for 24 h, followed by MPP.⁺(1 mM) for 48 h)