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Table 3 Univariate analysis of patients with CAA-ICH classified by the presence of postoperative rebleeding

From: Association of antithrombotic therapy with postoperative rebleeding in patients with cerebral amyloid angiopathy

 

Rebleeding( +)

(n = 12)

Rebleeding(-)

(n = 38)

P value

Character

 Age, median (range), year

78.5 (71–86)

78 (57–89)

0.356

 Female, No. (%)

10 (83)

24 (63)

0.172

 Hypertension, No. (%)

6(50)

15 (39)

0.738

 Diabetes, No. (%)

2 (17)

0

0.054

 Dementia, No. (%)

4 (33)

11 (29)

0.518

 Antithrombotic therapy, No. (%)

7 (58)

9 (24)

0.032

  Anticoagulant therapy, No. (%)

3 (25)

2 (5)

0.082

  Antiplatelet therapy, No. (%)

4 (33)

7 (18)

0.240

Systemic factor

 Hematoma vol. (before)*1, Mean (SD), mL

85 (36)

81 (32)

0.721

 Hematoma vol. (after)*2, Mean (SD), mL

7 (6)

6 (6)

0.687

 Hematoma vol. (rebleed)*3, Mean (SD), mL

28 (14)

6 (6)

 < 0.001

 Systolic blood pressure, Mean (SD), mmHg

184 (25)

173 (34)

0.281

 Diastolic blood pressure, Mean (SD), mmHg

88 (30)

84 (22)

0.605

 Preoperative PT-INR, Mean (SD)

1.3(0.64)

1.0(0.12)

0.099

 Preoperative APTT, Mean (SD)

29(8)

28(4)

0.521

 Surgeon’s experience, Mean (SD), year

4.6(1.8)

5.2(2.9)

0.528

 Surgical time, Mean (SD), minute

196 (60)

188 (68)

0.731

 Intraoperative bleeding volume, Mean (SD), ml

508 (435)

216 (160)

0.042

Outcome

 Hospital stays, Mean (SD), day

25(20)

31(18)

0.391

 mRS 0–3 at the discharge, No. (%)

0

11 (28)

0.032

 mRS 6 at the discharge, No. (%)

5 (42)

3 (8)

0.014

  1. CAA Cerebral amyloid angiopathy, ICH Intracerebral hemorrhage, SD Standard deviation, mRS Modified Rankin Scale, PT-INR Prothrombin Time-International Normalized Ratio, APTT Activated partial thromboplastin time
  2. *1: Preoperative hematoma volume, *2: Residual hematoma volume immediately after surgery, *3: Hematoma volume after rebleeding
  3. The mRS score 0 is no symptoms at all, 1 is no significant disability despite symptoms, 2 is slight disability, 3 is moderate disability, 4 is moderately severe disability, 5 is severe disability, and 6 is death