Articles

Paediatric intracranial meningiomas: eight-year experience with 32 cases

The information about paediatric meningiomas is poor. The purpose of this study was to review the clinical characteristic, treatment considerations and prognosis of paediatric meningiomas.

Authors: Ming-chao Fan, Wei Fang, Ke Liu, Chao Wang, Wen-shuai Deng, Peng Sun and Wan-zhong Tang

Moyamoya disease associated with ankylosing spondylitis in a 9-year-old child: a case report

Ankylosing spondylitis was reported to associate with an increased risk of cerebrovascular diseases. In this article, we aimed to report the first case of ankylosing spondylitis associated with moyamoya diseas...

Authors: Fan Yang, Peicong Ge and Xun Ye

Decompressive craniectomy for malignant middle cerebral artery infarctions: a meta-analysis

Decompressive craniectomy (DC) has been the classical management for malignant middle cerebral artery infarctions (mMCAI) in clinical practice. However, the association between DC and mMCAI remains unclear. Th...

Authors: Long Xu, Te Lu, Xiaogang Tao, Dandan Wang, Weiming Liu, Jingsheng Li and Baiyun Liu

Extended endoscopic endonasal approach for pituitary adenoma: a single-center experience of 171 patients

Pituitary adenoma (PA) is a common intracranial tumor and surgical treatment is considered to be the best treatment for most patients. The extended endoscopic endonasal approach (EEEA) has been used to treat i...

Authors: Xiaobing Jiang, Zhen Liu, Xing Huang, Haijun Wang and Hongyang Zhao

Inflammatory myofibroblastic tumor of the right frontal lobe

We aim to present an unique case of inflammatory myofibroblastic tumor (IMT) of the brain parenchyma and study the clinical presentation, imagine characteristic, intraoperative findings, and histopathology fea...

Authors: Xuejian Wang, Zhifeng Wang, Yang Chen and Ming Qian

Expression of MICU1 after experimental focal cerebral ischemia in adult rats

Mitochondrial Ca²⁺ uptake is a pivotal pathophysiological process for neuronal survival when subjected to ischemic insult. Mitochondrial calcium uptake 1 (MICU1) has been demonstrated as a key regulator of the mi...

Authors: Kun Zhang, Jiajia Yan, Liang Wang, Xinying Tian, Tong Zhang, Bin Li, Wang Wang, Li Guo and Xiaoyun Liu

Clinical and imaging features of subependymal giant cell astrocytoma: report of 20 cases

Subependymal giant cell astrocytoma (SEGA) is a clinically benign brain tumor associated with tuberous sclerosis complex (TSC). There are still controversies on early diagnosis of the tumor.

Authors: Guang-Hai Mei, Xiao-Xia Liu, Ping Zhou and Ming Shen

Diagnostic evaluation of patients with disorders of consciousness with diffusion tensor imaging

With the development of emergency and intensive medical technologies, the survival rate of traumatic brain injury has greatly increased. More and more patients have been converted from severe coma to alleviate...

Authors: Long Xu, Yi Yang, Er’an Guo, Xiaogang Tao, Te Lu, Runfa Tian, Zhu Chen, Xiaoyu Xia, Qingxia Tao, Mingmei Ge, Jianghong He, Jingsheng Li and Jizong Zhao

Intracerebral malignant melanoma presenting as an Arteriovenous Malformation: case report and literature review

The authors introduced a rare case of intracranial malignant melanoma.

Authors: Yajuan Tang, Yong Hou, Bruhaspaty Prasad, Wuyang Yang and Junxing Wang

A case report of the unilateral approach to the ruptured right ICA aneurysm together with tuberculum sella meningioma and left ICA aneurysm

Tuberculum sellae meningioma associated with aneurysm is extremely rare with a limited number of individual cases previously reported. Because of the complicated anatomical structure of the skull base, comorbi...

Authors: Jiu Geng Feng, Min Jun Wei, Rong Hua Feng, Tao Hong and Chun Hui Zeng

Clinical features of patients with pituitary stalk thickening: a review of 159 cases from one medical center

Pituitary stalk thickening (PST) used as an imaging diagnosis plays a major role in diagnosis and treatment of the hypothalamus and pituitary disease at an early stage. Up until now, several lines of systemati...

Authors: Yanjiao Cai, Xuefei Shou, Zhaoyun Zhang, Hongying Ye, Yao Zhao, Yongfei Wang, Rong Xie, Shiqi Li and Yiming Li

Titanium mesh implants exposure after cranioplasty in two children: involvement of osteogenesis?

Although technically regarded as a simple procedure, titanium mesh cranioplasty could lead to various surgical complications, including postoperative implant exposure. However, there is little data available o...

Authors: Han-song Sheng, Fang Shen, Mao-de Wang, Jian Lin, Fen-chun Lin, Bo Yin and Nu Zhang

Nonketotic hyperglycemia-related epileptic seizures

To investigate nonketotic hyperglycemia (NKH)-related epileptic clinical features and pathogenesis, and improve the diagnosis and treatment.

Authors: Xuejian Wang

Parkinsonism-hyperpyrexia syndrome after withdrawal of antiparkinsonian drugs and deep brain stimulation surgery

Parkinsonism-hyperpyrexia syndrome (PHS) is a rare but potentially fatal condition in patients with Parkinson’s disease. Deep brain stimulation (DBS) is a widely used and efficacious treatment for advanced Par...

Authors: Chun-Lei Han, Yan Ge, Da-Wei Meng, Jian-Guo Zhang and Fan-Gang Meng

Hemispheric developmental venous anomaly draining into a vein of Galen varix: a case report and literature review

Developmental venous anomaly (DVA), previously known as “venous angioma”, is the most common cerebral vascular malformation, but hemispheric DVA is extremely rare.

Authors: Hangzhe Xu, Jun Zheng, Gao Chen and Jingsen Chen

Ventriculo-peritoneal shunt trans-anal protrusion causing Escherichia coli ventriculitis in child: Case report and review of the literature

Ventriculo-peritoneal shunting is an effective treatment for hydrocephalus, bowel perforation by peritoneal catheters is an extremely rare complications associated with this procedure.

Authors: Yuhan Liu, Chunde Li and Yongji Tian

Dissecting aneurysms of the distal segment of the posterior cerebral artery: clinical presentation and endovascular management

We aimed to evaluate the clinical presentations and report the acceptable clinical and angiographic outcome of the distal posterior cerebral artery (PCA) dissecting aneurysms with parent artery occlusion (PAO).

Authors: Zenghui Qian, Xin Feng, Huibin Kang, Xiaolong Wen, Wenjuan Xu, Youxiang Li, Chuhan Jiang, Zhongxue Wu and Aihua Liu

Neuroenteric cyst of the left lateral ventricle: case report and review of the literature

Intracranial supratentorial neuroenteric cysts are very rare lesions in the central nervous system. We described a neuroenteric cyst of the left lateral ventricle in a 38-year old male, which had been confirme...

Authors: Xiaoyang Ling, Shaofeng Yang, Zhengxiang Luo, Wenbing Zhang, Yansong Zhang and Penglai Zhao

Media coverage and public awareness on bioethics perception of emerging biomedical therapies

Bioethics falls within the controversial ethical issues from the new advances and emerging technology in pre-clinical and clinical settings which inspired medical policy and practice. The purpose of this paper...

Authors: Sandra Acosta, Tam Tran, Jerel Mair, Obi Okonkwo, Brett Larose and Cesar V. Borlongan

An update on stem cell therapy for neurological disorders: cell death pathways as therapeutic targets

Here, we compiled ten papers detailing recent strides in the field of stem cell therapy, which address critical issues relevant to pursuing this experimental treatment for clinical applications in brain disord...

Authors: Sydney Corey, Shaila Ghanekar, Jake Sokol, John H. Zhang and Cesar V. Borlongan

Repeated multiple intracranial hemorrhages induced by cardiac myxoma mimicking cavernous angiomas: a case report

Repeated intracranial hemorrhages caused by cardiac myxoma is very rare. It is essential for physicians to be aware of such uncommon clinical feature of myxoma.

Authors: Kai Quan, Jianping Song, Wei Zhu, Liang Chen, Zhiguang Pan, Peiliang Li and Ying Mao

Human brain arteriovenous malformation: an analysis of differential expressed genes

Much still remains unknown about the pathogenesis of brain arteriovenous malformations (AVMs). Previous studies have revealed the abnormal expression of various angiogenesis-related genes in AVMs. To further u...

Authors: Xing Liu, Guolu Meng, Tengfei Yu, Xiangjiang Lin, Liwei Zhang, Xiaobin Fei, Junting Zhang, Zhen Wu, Shengze Deng, Shunlin Ren, Shuo Wang and Jizong Zhao

The relationship between mobile phone use and risk of brain tumor: a systematic review and meta-analysis of trails in the last decade

The aim of the present meta-analysis was to identify whether there was a relationship between mobile phone use and risk of brain tumor. A comprehensive search strategy was developed, and studies were eliminate...

Authors: Lige Leng

Pathological links between stroke and cardiac arrest

There may be a pathological connection between cardiac failure and ischemic stroke. In this article we describe pertinent research that demonstrates subsequent death of cardiac and neural myocytes in the post ...

Authors: Shaila Ghanekar, Sydney Corey, Trenton Lippert and Cesar V. Borlongan

Translating amniotic fluid-derived stem cells for transplantation in stroke

This article discusses possible applications of cells derived from human amniotic fluid in regenerative medicine, specifically in stroke therapy. Recent studies have evaluated amniotic fluid as a viable source...

Authors: Jake Sokol, Trenton Lippert, Cesar V. Borlongan and Liborio Stuppia

A rare case of giant solitary spinal B cell lymphoblastic lymphoma

Common B cell lymphoma locations are lymph nodes, skin, bone, mediastinum and it accounts for 2 % of NHL. Giant solitary spinal B-LBL has not yet been described.

Authors: Hermann Adonis N’da, Kporou Landry Drogba, Louis Derou, Slim Alban Mbende, Dominique N’dri Oka and Vincent Ba Zézé

Translational lab-to-clinic hurdles in stem cell therapy

Several experimental therapeutics have been demonstrated to be safe and effective in animal models of neurological disorders, but have failed when they reached the clinic. Postulated factors that affected the ...

Authors: Sydney Corey, Trenton Lippert and Cesar V. Borlongan

Mesenchymal stem cell-based therapy for ischemic stroke

Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently a...

Authors: Johnathon D. Anderson, Missy T. Pham, Zelenia Contreras, Madeline Hoon, Kyle D. Fink, Henrik J. Johansson, Julien Rossignol, Gary L. Dunbar, Megan Showalter, Oliver Fiehn, Charles S. Bramlett, Renee L. Bardini, Gerhard Bauer, Brian Fury, Kyle J. Hendrix, Frederic Chedin…

Biomaterial applications in neural therapy and repair

The use of biomaterials, such as hydrogels, as a scaffold to deliver cells and drugs is becoming increasingly common to treat neurological conditions, including stroke. With a limited intrinsic ability to rege...

Authors: Harmanvir Ghuman and Michel Modo

Computational fluid dynamics analysis on recurrence of simple coiling intracranial aneurysms with remnant neck

Hemodynamic factors are considered to play an important role in the initiation and recurrence of cerebral aneurysms. However, hemodynamic characteristics leading to the recurrence of aneurysms is not well reco...

Authors: Xilong Yu, Gang Lu, Shengzhang Wang, Lei Huang, Liang Ge, Jun Wan, Ruoyu Di, Yeqing Jiang and Xiaolong Zhang

MicroRNAs as biomarkers in molecular diagnosis of refractory epilepsy

MicroRNA (miRNA) is a type of endogenous non-coding RNA that can regulate cell proliferation, differentiation, invasion, apoptosis and several other biological activities by specially inducing gene silencing, ...

Authors: Xiaofeng Wang, Hang Yin, Alyson M. Rich, Yuqiang Sun, Zeshi Tan, Xiaodong Luo, Ningwei Che, Minghai Wei and Jian Yin

Omentum transposition for treatment of Alzheimer disease in China

A paper was published in a Chinese medical journal that suggested that the placing of an intact vascularized omental pedicle would increase cerebral blood flow and could decelerate the development of Alzheimer...

Authors: Harry S. Goldsmith

Lab-to-clinic application of stem cell therapy for stroke

Stem cell therapy or “cell therapy” has been demonstrated to be a potent treatment intervention in animal models of acute ischemic stroke, and recently has been introduced as an experimental therapy in early p...

Authors: Mia C. Borlongan, Sonya Kong and David C. Hess

Clinical study of quality of life of traumatic brain injury patients after decompressive craniectomy and related influencing factors

Decompressive craniectomy (DC) in traumatic brain injury (TBI) patients has been subject of debate for neurosurgeons since long time. Our goal in this study is to evaluate the quality of life of these patients...

Authors: Roodrajeetsing Gopaul, Zong Dang Wei, Jun Yan, Fan Yong Gong and Shao Wen Xiao

Could cough be an intraoperative indicator for venous air embolism in deep brain stimulation surgeries?: experiences from a large case series

Deep brain stimulation (DBS) surgery is usually performed with the patients located in a half-sitting position. Therefore, complications associated with such position accompany, such as venous air embolism (VA...

Authors: Lin Shi, Chao-Cai Zhang, Jun-Ju Li, Guan-Yu Zhu, Ying-Chuan Chen and Jian-Guo Zhang

Single stage complete resection of giant dumbbell lumbar ganglioneuroma: a case report and review of the literature

Ganglioneuroma is a rare benign tumor, which is usually located in the posterior mediastinum and retroperitoneum. Occasionally, it involves the paraspinal region with intraspinal extension and becomes dumbbell...

Authors: Zuowei Wang, Xingwen Wang, Fengzeng Jian and Li Chen

The diagnosis and management of hypothalamic hamartomas in children

Hypothalamic hamartoma (HH) is a rare developmental malformation often characterized by gelastic seizures. Recent advances in treating HH have led to dramatic improvements. However, clinical protocol of HH is ...

Authors: Baocheng Wang and Jie Ma

Endoscopic anatomical study on anterior communicating artery aneurysm surgery by endonasal transphenoidal approach

Endonasal transphenoidal approach by neuroendoscopy has its own advantage, such as direct access, invasive, better visualization of the anterior communicating artery aneurysm and so on. The study is to provide...

Authors: Junwei Ma, Zhimin Wang, Niankai Zhang, Shengshan Li, Dongyi Jiang and Hanchun Chen

Nocardial brain abscess in an immunocompetent patient and review of literature

Nocardial brain abscesses are associated with significant morbidity and mortality rates. The optimal management remains unclear.

Authors: Yinian Zhang, Wei Zhu, Qiao li, Boru Hou, Yanfei Jia, Naili Wei and Yawen Pan

Subdural hemorrhages in acute lymphoblastic leukemia: case report and literature review

Acute lymphoblastic leukemia is a rare hematological malignancy. Pure subdural hemorrhages in a patient with acute lymphoblastic leukemia patient are extremely rare.

Authors: Rui Yin, Cai-Xia Qiu, Xiao-Hui Dong and Ye-Long Chen

Three-dimensional printing technology for treatment of intracranial aneurysm

The development of three-dimensional (3D) printing technology provides a new method for surgical treatment, but currently there are few reports on its application in the treatment of aneurysm. The aim of the p...

Authors: Yin Kang, Liang-Hong Yu, Tao Xu, Shu-Fa Zheng, Pei-Sen Yao, Man Liu, Yuan-Xiang Lin, Zhang-Ya Lin, Xiao-Min Fan and De-Zhi Kang

Aneurysmal isolated intracerebral hemorrhage and/or intraventricular hemorrhage without subarachnoid hemorrhage: a rare and perplexing scenario in neurosurgical practice

Ruptured aneurysms with a presentation of intracerebral hemorrhage (ICH) and/or intraventricular hemorrhage (IVH) without subarachnoid hemorrhage (SAH) are rarely reported. Issues on the clinical characteristi...

Authors: Guichen Li, Xiaobo Zhu, Yang Zhang, Jinchuan Zhao, Xianfeng Gao and Kun Hou

Low grade astrocytoma transformating primitive neuroectodermal tumour in an adult? A case report and review of literature

Supratentorial primitive neuroectodermal tumors (sPNET) are rarely occurred in adults. Only 39 cases have been reported in the past decade. The transformation from low grade to aggressive astrocytoma is well k...

Authors: Xiaofeng Wang, Yuqiang Sun, Zeshi Tan, Anlong Ji, Xu Sun, Xinyu Li, Ningwei Che, Kang Yang, Yaoling Liu, Xiaodong Luo, Guanyu Wang, Lan Luan, Minghai Wei and Jian Yin

Transient mutism following neuroendoscopy in children; report of two cases

Since the introduction of neuro-endoscopy by Walter Dandy and his colleagues in the early 1920's, several efforts has been made to improve this tool for treatment of hydrocephalus, brain tumors, arachnoid cyst...

Authors: Nima Derakhshan and Mohammad Sadegh Masoudi

Retrosigmoid-transtentorial approach for petroclival meningiomas: operative technique and clinical outcome

Petroclival meningiomas (PCMs) are technically challenging lesions. Although the standard retrosigmoid approach is one of the most effective approaches, this route may have some limitations for the tumors exte...

Authors: Zijin Zhao, Xianrui Yuan, Jian Yuan, Jun Su, Xiangyu Wang, Weixi Jiang, Zefeng Peng, Xuejun Li and Qing Liu

The cultivation of epilepsy neurosurgeons: requirements and challenges

Epilepsy surgery has been accepted as an effective treatment in drug-resistant focal epilepsy. However, the number of epilepsy neurosurgeons is not enough in China compared with the huge demand. The content of...

Authors: Kai Zhang, Jianguo Zhang, Yanshan Ma, Xiaoqiu Shao, Wenhan Hu and Baotian Zhao

Identification of OPN, TNC and E-selectin as potential recognition proteins in cerebral vasospasm after subarachnoid hemorrhage

Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is a serious and significant health problem in the worldwide. There are still no effective therapies for treatment of CVS in patients suffering from...

Authors: Min Jun Wei, Jiu Geng Feng, Zhi Qun Jiang, Chun Hui Zeng, Li Ping Jiang and Tao Hong

Intracranial foreign body through the sagittal sinus: case report and review of literature

To investigate therapeutic effect of surgery that removes an intracranial foreign body through the intracranial sagittal sinus with help of intraoperative navigation and intraoperative fluorescein angiography.

Authors: Roodrajeetsing Gopaul, Wen Shao Xiao, Jun Yan and Dang Zong Wei

Erratum to: Isolated intradural Rosai-Dorfman disease of the spine: report of two cases

Authors: Yu Xin, Hui Shen, Desheng Kong, Wenqing Jia, Hai Liu and Jun Yang

Laminectomy by craniotome for huge spinal extradural arachnoid cyst: a case report

Spinal extradural arachnoid cyst is extremely rare. The longest SEACs that have been reported in previous studies involved no more than 5 spinal segments. This study presents a case of SEAC diagnosed from T9 t...

Authors: Bo Jin, Ji-zong Zhao, Han-bin Wang, Ke-da Wang, Long-qi Liu and Yi-bing Su