Fig. 1

The expression of CSF S100B increased along with the Fisher grading of patients and decreased as time went on. The S100B in CSF was measured by ECLIA assay at day 2-4, 6, 8, 10, and 12 after aSAH attacked. a It indicated that the S100B level increased along with the Fisher grading at the same day after rupture. *P < 0.05, **P < 0.01, and ***P < 0.001, compared to the Grade 1. b The CSF S100B decreased in a time-dependent manner significantly in Grade 1 and 2, but not significantly in Grade 3, 4 and 5. ##P < 0.01, ###P < 0.001, ***P < 0.001, compared to the Baseline sample. c The CSF S100B levels in patients treated with surgical clipping or endovascular coiling at each day. There are no statistical differences between the two operating methods. CSF, cerebrospinal fluid. aSAH, aneurysmal subarachnoid hemorrhage