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Table 1 A summary of the cell types that express SR-B1, and their functions pertaining to the pathology of stroke and other neurological disorders

From: Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke

Cell typeFunctionReference
Epithelial cells- Upregulates wound tissue repair by affecting the proliferative and migratory properties of keratinocytes
- Regulates ceramide levels and maintain barrier function of keratinocytes
- Vitamin E uptake might be regulated by SR-B1 in pneumocytes
- Functions as plasma membrane cholesterol sensor
Muresan et al. [34], Muresan et al. [35], Kolleck et al. [36], Morel et al. [20]
Smooth muscle cells- rHDL inhibits smooth muscle cell chemokine expression, p65, and proliferation through SR-B1
- HDL-associated lysosphinoglipids function to reduce ROS generation, which requires SR-B1 coordinate signaling
Van der Vorst et al. [37], Tolle et al. [38]
Monocytes- Subclinical endotoxemia promotes atherosclerosis by converting monocytes into a persistent inflammatory state with reduced SR-B1Geng et al. [39]
Macrophages- SR-B1 invalidation reduces free-cholesterol-induced apoptosis and promotes atherosclerosisGalle-Treger et al. [40]
Endothelial cells- Functions as plasma membrane cholesterol sensor
- Binding of SR-B1 with HDL activates endothelial NO synthase and stimulates endothelial cell migration
- Apolipoprotein A-1 promotes endothelial repair through SR-B1
- SR-B1 acts as a mechanosensor in response to shear stress
- SR-B1 is involved in transendothelial cholesterol transport
Saddar et al. [41], Yuhanna et al. 2001, Seetharam et al. [42], He et al. [43], Zhang et al. [44], Miao et al. [21]
Steroidogenic cells- Estrogen increases brain SR-B1 levels
- SR-B1 facilitates vasorelaxation pathway via interactions with DHEA-enriched HDL
Srivastava et al. [45], Paatela et al. [46]
Astrocytes-Impairment of amyloid β uptake in Alzheimer’s correlated with a lower expression of SR-B1Iram et al. [47]
Hepatocytes- Mediates uptake of HDL-derived cholesterol esterActon et al. [17]