Table 1 Factors that cause ferroptosis in EBI after SAH
From: Ferroptosis in early brain injury after subarachnoid hemorrhage: review of literature
Author | Year | Mechanism for the factors | Setting |
|---|---|---|---|
Gao, S. Q. et al. [147] | 2020 | Decrease of GPX4 expression | Rats and in vitro model |
Cao, Y. et al. [194] | 2021 | Expression of Gpx4 and ACSL4 and Cox2 | Rats and in vitro model |
Heinsberg, L. W. et al. [195] | 2021 | Iron homeostasis pathway DNA Methylation.STEAP3 metalloreductase | Clinical |
Kuang, H. et al. [175] | 2021 | Inhibiting p53-induced ferroptosis | Rats |
Li, Y. et al. [30] | 2021 | Fpn expression and the iron content | Rats and in vitro model |
Qu, X. et al. [133] | 2021 | ACSL4 | Rats |
Zhang, H. et al. [113] | 2021 | DMT1 signaling activation. Hepcidin | Rats |
Zheng, B. et al. [196] | 2021 | Autophagy dependent ferroptosis | Rats |
Gao, S et al. [131] | 2022 | 15-lipoxygenase-1-mediated microglia and endothelial cell ferroptosis | Rats and in vitro model |
Liang, Y. D. et al. [171] | 2022 | Activation of ferritinophagy | Rats |
Liu, Y. et al. [180] | 2022 | Aquaporin 4 depolarization-enhanced transferrin infiltration | Rats |
Qu, W. et al. [192] | 2022 | Ferroptosis of M1 microglia | Rats |
Tao, Q. et al. [197] | 2022 | Autophagy-dependent ferroptosis in microglia | Rats |
Yuan, B. et al. [150] | 2022 | Activation of SIRT1 alleviates ferroptosis in the early brain injury after subarachnoid hemorrhage | Rats and in vitro model |
Chen, J. et al. [154] | 2023 | Netrin-1 alleviates early brain injury by regulating ferroptosis via the PPARγ/Nrf2/GPX4 signaling pathway following subarachnoid hemorrhage | Rats |
Jiao, D. et al. [148] | 2023 | QCT increased the expression levels of GPX4, xCT, and FPN1, while downregulated TfR1 | Rats |
Cao, C et al. [198] | 2023 | Restoring system xc- activity by xCT overexpression inhibited neuronal ferroptosis and improved neurological deficits after experimental subarachnoid hemorrhage | Rats |
Ma, S. et al. [155] | 2023 | Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage | Rats |
Zhang, J. et al. [177] | 2023 | Menaquinone-4 attenuates ferroptosis by upregulating DHODH through activation of SIRT1 after subarachnoid hemorrhage | Rats |