Moshe SL, Perucca E, Ryvlin P, et al. Epilepsy: new advances. Lancet. 2015;385(9971):884–98.
Article
PubMed
Google Scholar
Devinsky O. Patients with refractory seizures. N Engl J Med. 1999;340(20):1565–70.
Article
CAS
PubMed
Google Scholar
Annamaria V. Before epilepsy unfolds: finding the epileptogenesis switch. Nat Med. 2012;18:1626–7.
Article
Google Scholar
Berg AT. Understanding the delay before epilepsy surgery: who develops intractable focal epilepsy and when? CNS Spectr. 2004;9(2):136–44.
Article
PubMed
Google Scholar
Shneker BF, Fountain NB. Epilepsy. Dis Mon. 2003;49(7):426–78.
Article
PubMed
Google Scholar
Chang BS, Lowenstein DH. Epilepsy. N Engl J Med. 2003;349(13):1257–66.
Article
PubMed
Google Scholar
Tatum 4th WO. Mesial temporal lobe epilepsy. J Clin Neurophysiol. 2012;29(5):365–65.
Google Scholar
Thom M. Hippocampal sclerosis: progress since Sommer. Brain Pathol. 2009;19:565–72.
Article
PubMed
Google Scholar
Thom M. Reivew: Hippocampal sclerosis in epilepsy: a neuropathology review. Neuropathol Appl Neurobiol. 2012;40(5):520–43.
Article
Google Scholar
Cendes F, Sakamoto AC, Spreafico R, et al. Epilepsy associated with hippocampal sclerosis. Acta Neuropathol. 2014;128(1):21–37.
Article
CAS
PubMed
Google Scholar
Dupuis N, Auvin S. Inflammation and epilepsy in the developing brain: clinical and experimental evidence. CNS Neurosci Ther. 2015;21(2):141–51.
Article
PubMed
Google Scholar
Nash TE, Del Brutto OH, Butman JA, et al. Calcific neurocysticercosis and epileptogenesis. Neurology. 2004;62(11):1934–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Herman ST. Epilepsy after brain insult: targeting epileptogenesis. Neurology. 2002;59(9 Suppl 5):S21–6.
Article
PubMed
Google Scholar
Guerrini R, Sicca F, Parmeggiani L. Epilepsy and malformations of the cerebral cortex. Epileptic Disord. 2003;5 Suppl 2:S9–S26.
PubMed
Google Scholar
Sutula TP. A glimpse into abnormal cortical development and epileptogenesis at epilepsy surgery. Neurology. 1998;50(1):8–10.
Article
CAS
PubMed
Google Scholar
Perucca E. Pharmacoresistance in epilepsy. How should it be defined? CNS Drugs. 1998;10:171–9.
Article
Google Scholar
Berg AT, Vickreg BG, Testa FM, et al. How long does it take epilepsy to become intractable? A prospective investigation. Ann Neurol. 2006;60:73–9.
Article
PubMed
Google Scholar
Kwan P, Arzimanoglou A, Anne T. B, et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010;51(6):1069–77.
Article
CAS
PubMed
Google Scholar
Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342:314–9.
Article
CAS
PubMed
Google Scholar
David C. Henshall. MicroRNA and epilepsy: profiling, functions and potential clinical applications. Curr Opin Neurol. 2014;27(2):199–205.
Article
Google Scholar
Galanopoulou AS, Moshé SL. In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies. Biomark Med. 2011;5(5):615–28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pitkäen A, Lukasiuk K. Molecular biomarkers of epileptogenesis. Biomark Med. 2011;5(5):629–33.
Article
Google Scholar
Jimenez-Mateos EM, Henshall DC. Epilepsy and microRNA. Neuroscience. 2013;238:218–29.
Article
CAS
PubMed
Google Scholar
Henshall DC. MicroRNAs in the pathophysiology and treatment of status epilepticus. Front Mol Neurosci. 2013;6:37.
Article
PubMed
PubMed Central
Google Scholar
Enciu AM, Popescu BO, Gheorghisan-Galateanu A. MicroRNAs in brain development and degeneration. Mol Biol Rep. 2012;39(3):2243–52.
Article
CAS
PubMed
Google Scholar
Song YJ, Tian XB, Zhang S, et al. Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/b. Brain Res. 2011;1387:134–40.
Article
CAS
PubMed
Google Scholar
Hu K, Xie YY, Zhang C, et al. MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis poststatus epilepticus. BMC Neurosci. 2012;13:1–14.
Article
CAS
Google Scholar
Bot AM, Debski KJ, Lukasiuk K. Alterations in miRNA levels in the dentate gyrus in epileptic rats. PLoS One. 2013;8:e76051.
Article
CAS
PubMed
PubMed Central
Google Scholar
GorterJA IA, White I. Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy. Neurobiol Dis. 2013;62:508–20.
Article
Google Scholar
Aronica E, Fluiter K, Iyer A, et al. Expression pattern of miR- 146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. Eur J Neurosci. 2010;31:1100–7.
Article
CAS
PubMed
Google Scholar
Omran A, Peng J, Zhang C, et al. Interleukin-1beta and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy. Epilepsia. 2012;53:1215–24.
Article
CAS
PubMed
Google Scholar
Ashhab MU, Omran A, Kong H, et al. Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy. J Mol Neurosci. 2013;51:950–8.
Article
CAS
PubMed
Google Scholar
Liu DZ, Tian Y, Ander BP, et al. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010;30:92–101.
Article
PubMed
Google Scholar
Gorter JA, Iyer A, et al. Hippocampal subregion -specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy. Neurobiol Dis. 2014;62:508–20.
Article
CAS
PubMed
Google Scholar
Blondal T, et al. Assessing sample and miRNA profile quality in serum and plasma or other biofluids. Methods. 2013;59:S1–6.
Article
CAS
PubMed
Google Scholar
Kan AA, van Erp S, Derijck AA, de Wit M, Hessel EV, O’Duibhir E, de Jager W, Van Rijen PC, Gosselaar PH, de Graan PN, Pasterkamp RJ. Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cell Mol Life Sci. 2012;69:3127–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Landazuri P. Mesial temporal lobe epilepsy: a distinct electroclinical subtype of temporal lobe epilepsy. Neurodiagn J. 2014;54(3):274–88.
Article
PubMed
Google Scholar
Wetherington J, Serrano G, Dingledine R. Astrocytes in the epileptic brain. Neuron. 2008;58(2):168–78.
Article
CAS
PubMed
PubMed Central
Google Scholar
Smrt RD, Szulwach KE, Pfeif-fer RL, Li X, Guo W, Pathania M, et al. MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin lig- ase mind bomb-1. Stem Cells. 2010;28:1060–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krichevsky AM, Sonntag KC, Isacson O, Kosik KS. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells. 2006;24:857–64.
Article
CAS
PubMed
Google Scholar
Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell. 2007;27(3):435–48.
Article
CAS
PubMed
PubMed Central
Google Scholar
Peng J, Omran A, Ashhab MU, Kong H, Gan N, He F, Yin F. Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy. J Mol Neurosci. 2013;50(2):291–7.
Article
CAS
PubMed
Google Scholar
Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008;6:14.
Article
PubMed
PubMed Central
Google Scholar
Liu C, Teng ZQ, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010;6(5):433–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
McKiernan RC, Jimenez-Mateos EM, Sano T, Bray I, Stallings RL, Simon RP, Henshall DC. Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death. Exp Neurol. 2012;237(2):346–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao C, Sun G, Li S, Lang MF, Yang S, Li W, Shi Y. MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. Proc Natl Acad Sci U S A. 2010;107(5):1876–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brüstle O. MicroRNA-based promotion of human neuronal differentiation and subtype specification. PLoS One. 2013;8(3):e59011.
Article
CAS
PubMed
PubMed Central
Google Scholar
Agostini M, Tucci P, Killick R, Candi E, Sayan BS, di Val Cervo Rivetti P, Nicotera P, McKeon F, Knight RA, Mak TW, Melino G. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A. 2011;108(52):21093–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN, Gao FB. MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell. 2010;6(4):323–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sun G, Ye P, Murai K, Lang MF, Li S, Zhang H, Li W, Fu C, Yin J, Wang A, Ma X, Shi Y. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat Commun. 2011;2:529.
Article
PubMed
PubMed Central
Google Scholar
Edbauer D, Neilson JR, Fos-ter KA, Wang CF, See-burg DP, Batterton MN, et al. Regulation of synaptic structure and function by FMRP- associated microRNAs miR-125b and miR-132. Neuron. 2010;65:373–84.
Article
CAS
PubMed
Google Scholar
Lukiw WJ, Zhao Y, Cui JG. An NF-kappaB-sensitive microRNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem. 2008;283(46):31315–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schaefer A, O’Carroll D, Tan CL, et al. Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med. 2007;204(7):1553–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Davis TH, Cuellar TL, Koch SM, et al. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci. 2008;28:4322–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kaneko H, Dridi S, Tarallo V, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011;471:325–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tao J, Wu H, Lin Q, et al. Deletion of astroglial dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci. 2011;31:8306–19.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hebert SS, Papadopoulou AS, Smith P, et al. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet. 2010;19:3959–69.
Article
CAS
PubMed
Google Scholar
Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, et al. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science. 2010;328:1694–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang JS, Maurin T, Robine N, et al. Conserved vertebrate mir-451 provides a platform for Dicer independent, Ago2-meidated microRNA biogenesis. Proc Natl Acad Sci U S A. 2010;107(34):15163–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nudelman AS, DiRocco DP, Lambert TJ, Garelick MG, Le J, et al. Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. Hippocampus. 2010;20:492–8.
CAS
PubMed
PubMed Central
Google Scholar
Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW, et al. Mef2-mediated transcription of the miR379–410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009;28:697–710.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang X, Sun Y, Tan Z, Che N, Ji A, Luo X, Sun X, Li X, Yang K, Wang G, Luan L, Liu Y, Wei M, Yin J. Serum microRNA-4521 is a potential biomarker for focal cortical dysplasia with refractory epilepsy. Neurochem Res. 2016;41(4):905–12.
Article
CAS
PubMed
Google Scholar
Wang J, Tan L, Tan L, Tian Y, Ma J, Tan CC, Wang HF, Liu Y, Tan MS, Jiang T, Yu JT. Circulating microRNAs are promising novel biomarkers for drug-resistant epilepsy. Sci Rep. 2015;5:10201.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li MM, Li XM, Zheng XP, Yu JT, Tan L. MicroRNAs dysregulation in epilepsy. Brain Res. 2014;1584:94–104.
Article
CAS
PubMed
Google Scholar